Description

Biotinyl Cystamine-D4 is a high-purity, deuterated derivative of biotinyl cystamine, a key reagent for bioconjugation and labeling. This compound is specifically designed for use as a stable isotope-labeled internal standard in quantitative mass spectrometry, ensuring unparalleled accuracy in proteomic and metabolomic research. It is essential for scientists and manufacturers in the pharmaceutical, biotechnology, and diagnostic sectors who require precise quantification of biotinylated proteins, peptides, and other biomolecules.

Application

• Quantitative Mass Spectrometry: Serves as a critical internal standard for the accurate LC-MS/MS quantification of biotinylated analytes.
• Proteomics Research: Used in pull-down assays and affinity purification workflows to quantify protein-biotin interactions with high precision.
• Diagnostic Assay Development: Enables the creation of standardized, quantitative tests for biomarkers in clinical and research settings.
• Metabolomic Studies: Facilitates the precise measurement of biotin-related metabolic pathways.
• Drug Discovery & Development: Supports pharmacokinetic (PK) and pharmacodynamic (PD) studies of biotin-conjugated therapeutic agents.
• Quality Control Reference: Acts as a certified reference material (CRM) for calibrating analytical methods in GMP/GLP environments.

Basic Information

Product Name	Biotinyl Cystamine-D4
CAS No.	1322625-65-9
Molecular Formula	C14H20D4N4O2S2
Molecular Weight	348.52 g/mol
Synonyms	N-[6-(2-{2-[5-(2-Oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanoylamino]ethyl}disulfanyl-ethyl)-D4]biotinamide; Biotinylcystamine-d4; D4-Biotinyl Cystamine; Biotin-HPDP-d4 (related analog); 5-((2-((2-(5-((3aS,4S,6aR)-2-Oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamido)ethyl)disulfaneyl)ethyl)amino)-5-oxopentyl-d4; Deuterated Biotin Disulfide
EINECS	Contact for details

Quality Control

Every batch of Biotinyl Cystamine-D4 is manufactured under strict quality systems and undergoes comprehensive analytical testing to ensure identity, purity, and isotopic enrichment. We provide a detailed Certificate of Analysis (COA) with each shipment, which includes data from NMR, HPLC, and mass spectrometry. Our quality commitment aligns with the standards expected for high-value research chemicals and certified reference materials.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). For long-term storage under inert atmosphere, consider sealing under argon or nitrogen. Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment (D)	≥ 98 atom % D
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.