Description

4-n-[6-(Trideuteriomethoxy)Quinolin-8-Yl]Pentane-1,4-Diamine is a deuterated quinoline derivative, a specialized building block of significant interest in advanced pharmaceutical and agrochemical research. Its core value lies in the strategic incorporation of deuterium atoms, which can enhance the metabolic stability and pharmacokinetic profile of lead compounds. This high-purity intermediate is primarily needed by R&D scientists and process chemists in the pharmaceutical industry for the development of new drugs, as well as in the discovery of novel crop protection agents.

Application

• Pharmaceutical Intermediate: A key deuterated synthon for the research and development of novel drug candidates, particularly in oncology and CNS disorders.
• Metabolic Stability Studies: Used in medicinal chemistry to investigate the Deuterium Isotope Effect (DIE) and improve the metabolic half-life of potential therapeutics.
• Agrochemical Research: Serves as a building block in the synthesis of advanced, more persistent, and effective crop protection chemicals.
• Isotopic Labeling: Employed in the preparation of isotopically labeled compounds for use as internal standards in analytical methods like LC-MS.
• Chemical Biology Probes: Useful for creating tagged molecular probes to study biological pathways and target engagement.
• Process Chemistry & Scale-up: Supports route scouting and optimization for the commercial-scale synthesis of deuterated active pharmaceutical ingredients (APIs).

Basic Information

Product Name	4-n-[6-(Trideuteriomethoxy)Quinolin-8-Yl]Pentane-1,4-Diamine
CAS No.	1318852-20-8
Molecular Formula	C15H20D3N3O
Molecular Weight	261.38 g/mol
Synonyms	8-[4-Aminopentyl]amino-6-(trideuteriomethoxy)quinoline; 6-(Trideuteriomethoxy)-8-[(4-aminopentyl)amino]quinoline; 4-N-[6-(CD3O)-Quinolin-8-yl]pentane-1,4-diamine; Deuterated 8-Aminopentylamino-6-methoxyquinoline; 1318852-20-8; 4-(6-(Trideuteriomethoxy)quinolin-8-ylamino)pentan-1-amine
EINECS	Contact for details

Quality Control

Our 4-n-[6-(Trideuteriomethoxy)Quinolin-8-Yl]Pentane-1,4-Diamine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and development. Each lot undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation and deuterium incorporation verification. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	Off-white to light yellow solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Deuterium Incorporation (NMR/MS)	≥ 98 atom % D
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.