Description

Desethylcarbamoyl Cabergoline-D5 is a deuterated analog of a key cabergoline metabolite, specifically designed for use as an internal standard in quantitative analytical methods. This high-purity reference material is essential for ensuring accuracy and precision in pharmacokinetic and metabolic studies. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical testing facilities specializing in bioanalysis and drug metabolism.

Application

• Internal Standard for LC-MS/MS: Critical for the precise quantification of cabergoline and its metabolites in biological matrices such as plasma, serum, and urine.
• Drug Metabolism and Pharmacokinetics (DMPK) Studies: Enables accurate tracking of metabolic pathways and clearance rates in preclinical and clinical research.
• Bioanalytical Method Development and Validation: Serves as a stable, isotopically-labeled reference to improve method robustness, accuracy, and reproducibility.
• Pharmaceutical Quality Control: Used in impurity profiling and stability-indicating assays for cabergoline-based drug products.
• Forensic and Anti-Doping Analysis: Supports the detection and confirmation of cabergoline in forensic toxicology and sports doping control.

Basic Information

Product Name	Desethylcarbamoyl Cabergoline-D5
CAS No.	1316849-28-1
Molecular Formula	C24H32D5N3O2
Molecular Weight	~403.6 g/mol
Synonyms	N-Desethylcarbamoyl Cabergoline-d5; 1-((6-Allyl-8β-ergolin-1-yl)carbonyl)-1-[3-(dimethylamino)propyl]-3-(ethyl-d5)-urea; Cabergoline Metabolite-d5; Cabergoline-d5 Derivative; 8β-[(N-3-(Dimethylamino)propyl)-N-(ethyl-d5)carbamoyl]amino]-6-allylergoline; (8β)-6-Allyl-8-[[[3-(dimethylamino)propyl]amino]carbonyl]amino]-N-(ethyl-d5)ergoline-1-carboxamide
EINECS	Contact for details

Quality Control

Every batch of Desethylcarbamoyl Cabergoline-D5 is manufactured under strict quality management systems and undergoes comprehensive analytical characterization. We guarantee high chemical and isotopic purity, supported by a detailed Certificate of Analysis (COA) that includes data from NMR, HPLC, and mass spectrometry. Our quality protocols are designed to meet the stringent requirements of pharmaceutical reference standard applications.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label or COA. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC-MS)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-content)	≥ 98.0 atom % D
Chemical Purity	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.