Description

(E)-3-(2-(1H-Tetrazol-5-Yl)Vinyl)-6-Fluoro-1H-Indole is a high-purity, advanced pharmaceutical intermediate characterized by its unique molecular structure combining an indole and a tetrazole moiety. This compound is of significant value in medicinal chemistry for its role as a key building block in the synthesis of novel drug candidates, particularly those targeting G-protein-coupled receptors (GPCRs). It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of new therapeutic agents, especially in the areas of oncology, neurology, and metabolic diseases.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the synthesis of active pharmaceutical ingredients (APIs) for preclinical and clinical research.
• Medicinal Chemistry Research: Used as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• GPCR-Targeted Drug Development: Particularly valuable for creating novel ligands and modulators for G-protein-coupled receptors due to its structural features.
• Biochemical Assay Development: Employed in the development of high-throughput screening assays and biochemical probes.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations specializing in custom synthesis and process development for the pharmaceutical industry.
• Academic Research: Used in university and institutional labs for fundamental research in organic synthesis and bioorganic chemistry.

Basic Information

Product Name	(E)-3-(2-(1H-Tetrazol-5-Yl)Vinyl)-6-Fluoro-1H-Indole
CAS No.	1316695-35-8
Molecular Formula	C₁₁H₈FN₅
Molecular Weight	229.22 g/mol
Synonyms	6-Fluoro-3-[(E)-2-(1H-tetrazol-5-yl)ethenyl]-1H-indole; (E)-6-Fluoro-3-(2-(1H-tetrazol-5-yl)vinyl)-1H-indole; 3-[(E)-2-(1H-Tetrazol-5-yl)vinyl]-6-fluoro-1H-indole; 6-Fluoro-3-[(E)-2-(1H-tetrazol-5-yl)vinyl]indole; 6-Fluoro-3-(2-(1H-tetrazol-5-yl)vinyl)-1H-indole; CAS 1316695-35-8
EINECS	Contact for details

Quality Control

Our (E)-3-(2-(1H-Tetrazol-5-Yl)Vinyl)-6-Fluoro-1H-Indole is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality commitment aligns with the standards expected for pharmaceutical R&D, ensuring reliable and reproducible results for your critical research and development projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider storing under an inert atmosphere such as argon or nitrogen.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.