Description

(E)-3-(6-Fluoro-1H-Indol-3-Yl)Acrylonitrile CAS NO 1316695-32-5 is a high-purity fluorinated indole derivative featuring an acrylonitrile moiety, serving as a critical advanced pharmaceutical intermediate. Its value lies in its role as a versatile building block for constructing complex molecules, particularly in medicinal chemistry and drug discovery programs. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and fine chemical industries who require high-quality, structurally defined intermediates for synthesizing novel active compounds.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of potential drug candidates, especially those targeting central nervous system (CNS) disorders, oncology, and inflammation.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization due to its fluorinated indole scaffold and reactive acrylonitrile group.
• Agrochemical Synthesis: Serves as a building block for developing novel pesticides and herbicides, leveraging the biological activity of the indole structure.
• Fine Chemical Production: Employed in the custom synthesis of specialty chemicals, dyes, and functional materials.
• Bioconjugation & Probe Development: The acrylonitrile group can be utilized in click chemistry or Michael addition reactions for labeling and probe synthesis in biochemical research.

Basic Information

Item	Details
Product Name	(E)-3-(6-Fluoro-1H-Indol-3-Yl)Acrylonitrile
CAS No.	1316695-32-5
Molecular Formula	C11H7FN2
Molecular Weight	186.19 g/mol
Synonyms	(E)-3-(6-Fluoro-1H-indol-3-yl)acrylonitrile; (E)-3-(6-Fluoro-1H-indol-3-yl)-2-propenenitrile; 6-Fluoro-3-(2-cyanoethenyl)-1H-indole; trans-3-(6-Fluoro-1H-indol-3-yl)acrylonitrile; 3-(6-Fluoro-1H-indol-3-yl)acrylonitrile (E-isomer); 6-Fluoro-3-indoleacrylonitrile; Fluorinated indole acrylonitrile
EINECS	Contact for details

Quality Control

Our production of (E)-3-(6-Fluoro-1H-Indol-3-Yl)Acrylonitrile adheres to stringent quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, confirming compliance with customer specifications and relevant industry standards for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, handling and storage should minimize exposure to direct light.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.