Description

Artesunate-D3 CAS NO 1316303-44-2 is a deuterium-labeled analog of the potent antimalarial drug Artesunate, where three hydrogen atoms are replaced with deuterium. This stable isotope-labeled compound is a critical reference standard and internal standard for quantitative bioanalytical methods, ensuring accurate pharmacokinetic and metabolic studies. It is essential for pharmaceutical R&D laboratories, contract research organizations (CROs), and regulatory bodies involved in drug development, quality control, and forensic analysis of artemisinin-based therapies.

Application

• Bioanalytical Reference Standard: Serves as a certified internal standard for the precise quantification of Artesunate and its metabolites in biological matrices (plasma, serum, urine) using LC-MS/MS and GC-MS.
• Drug Metabolism and Pharmacokinetics (DMPK): Enables accurate tracking of drug absorption, distribution, metabolism, and excretion (ADME) studies in preclinical and clinical research.
• Pharmaceutical Quality Control: Used in the development and validation of analytical methods to ensure the purity, potency, and consistency of Artesunate active pharmaceutical ingredients (APIs) and finished dosage forms.
• Forensic and Anti-Counterfeiting Analysis: Aids in the authentication of pharmaceutical products and the investigation of drug quality in public health and regulatory compliance.
• Stable Isotope Tracing Studies: Facilitates research into the metabolic pathways and mechanisms of action of artemisinin derivatives.

Basic Information

Item	Detail
Product Name	Artesunate-D3
CAS No.	1316303-44-2
Molecular Formula	C19H25D3O8
Molecular Weight	387.43 g/mol
Synonyms	Dihydroartemisinin-12-α-succinate-D3; (3R,5aS,6R,8aS,9R,10S,12R,12aR)-Decahydro-3,6,9-trimethyl-3,12-epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin-10(3H)-one 12-(hydrogen succinate-D3); Artesunate-d3; [2H3]-Artesunate; Artesunic Acid-D3; Deuterated Artesunate
EINECS	Contact for details

Quality Control

Our Artesunate-D3 is manufactured under strict quality systems to meet the exacting requirements of analytical and research applications. Each batch is characterized and tested to ensure high chemical and isotopic purity. Comprehensive analysis includes identity confirmation by spectroscopic methods (NMR, IR, MS), purity assessment by HPLC, and determination of isotopic enrichment. A Certificate of Analysis (COA) detailing all specifications and test results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label or COA. Keep the container in a dry, cool, and well-ventilated area. For long-term storage, consider storing desiccated at -20°C.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (MS)	≥ 99.0 atom % D
Chemical Purity	≥ 95.0% (by HPLC, area %)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.