Description

2-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)benzo[d]thiazole is a high-value organoboron building block, specifically a benzothiazole-substituted pinacol boronic ester. This compound matters as a critical intermediate in modern synthetic chemistry, enabling precise carbon-carbon and carbon-heteroatom bond formation. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and materials science industries for constructing complex molecular architectures.

Application

• Suzuki-Miyaura Cross-Coupling Reactions: A key reagent for palladium-catalyzed coupling to introduce the benzothiazole moiety into complex molecules, a common scaffold in medicinal chemistry.
• Pharmaceutical Intermediate: Synthesis of active pharmaceutical ingredients (APIs) and drug candidates, particularly those targeting neurological disorders, oncology, and infectious diseases.
• Agrochemical Synthesis: Building block for developing novel fungicides, herbicides, and insecticides with enhanced efficacy.
• Materials Science & OLED Development: Used in the synthesis of organic semiconductors, light-emitting materials, and electron-transport layers for electronic devices.
• Ligand & Catalyst Preparation: Precursor for creating novel bidentate ligands and catalysts used in asymmetric synthesis.
• Chemical Biology Probes: Enables the tagging and study of biological systems through bioconjugation strategies.

Basic Information

Product Name	2-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)benzo[d]thiazole
CAS No.	1316275-48-5
Molecular Formula	C15H20BNO2S
Molecular Weight	289.20 g/mol
Synonyms	2-(Benzo[d]thiazol-2-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; Benzo[d]thiazole-2-boronic acid pinacol ester; 2-(1,3,2-Dioxaborolan-2-yl)benzothiazole (pinacol ester); 2-Boronobenzothiazole pinacol ester; 2-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1,3-benzothiazole; Bzthz-Bpin; CAS 1316275-48-5
EINECS	Contact for details

Quality Control

Our 2-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)benzo[d]thiazole is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR (1H, 13C, 11B), and GC/MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) with detailed specifications are provided for every shipment, supporting your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). The container should be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to maximize shelf-life stability, as organoboron compounds can be sensitive to moisture and oxygen over prolonged periods.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.