Description

(1R,2R,7R,7As)-1-Azido-7-Chlorohexahydro-1H-Pyrrolizin-2-Ol CAS NO 1315552-05-6 is a high-purity, stereochemically defined chiral building block of significant interest in advanced organic synthesis. Its unique pyrrolizine scaffold, functionalized with both an azide and a chloro group, makes it a versatile intermediate for constructing complex nitrogen-containing molecules. This compound is particularly valuable for research and development in the pharmaceutical industry, where it serves as a key precursor for the synthesis of novel active pharmaceutical ingredients (APIs) and other bioactive compounds.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the research and development of new drug candidates, particularly in medicinal chemistry programs targeting complex heterocycles.
• Click Chemistry Reagent: The azide functional group enables its use in copper-catalyzed azide-alkyne cycloaddition (CuAAC) reactions, a cornerstone of bioconjugation and materials science.
• Agrochemical Synthesis: Serves as a building block for developing novel pesticides and herbicides with specific stereochemical requirements for enhanced activity.
• Academic & Contract Research: Used in university and CRO laboratories for methodological studies in asymmetric synthesis and the construction of nitrogen-rich molecular architectures.
• Ligand & Catalyst Development: Potential precursor for synthesizing novel chiral ligands and organocatalysts used in enantioselective transformations.
• Material Science Research: Investigated for incorporation into specialty polymers or functional materials where its specific 3D structure and reactivity are advantageous.

Basic Information

Item	Details
Product Name	(1R,2R,7R,7As)-1-Azido-7-Chlorohexahydro-1H-Pyrrolizin-2-Ol
CAS No.	1315552-05-6
Molecular Formula	C7H11ClN4O
Molecular Weight	202.64 g/mol
Synonyms	1-Azido-7-chlorohexahydro-1H-pyrrolizin-2-ol, (1R,2R,7R,7aS)-1-Azido-7-chlorohexahydro-1H-pyrrolizin-2-ol; 7-Chloro-1-azidohexahydro-1H-pyrrolizin-2-ol; (1R,2R,7R,7aR)-1-Azido-7-chlorohexahydro-1H-pyrrolizin-2-ol (enantiomer); Azidochloropyrrolizinol; Pyrrolizine azide chloro intermediate
EINECS	Contact for details

Quality Control

Our (1R,2R,7R,7As)-1-Azido-7-Chlorohexahydro-1H-Pyrrolizin-2-Ol is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high chemical purity. Each lot is characterized using advanced analytical techniques, including HPLC, NMR, and chiral analysis, to confirm identity, purity, and stereochemical integrity. Certificates of Analysis (COA) detailing all relevant specifications are provided with every shipment. Our quality system is designed to support cGMP compliance for use in regulated research environments.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at 2-8°C or as specified on the label or COA. Due to its light-sensitive and easily oxidized nature, prolonged exposure to light, air, or elevated temperatures should be avoided to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.