Description

(R)-3-Aminotetrahydrothiophene-3-Carboxylic Acid CAS NO 1315054-23-9 is a high-value, non-proteinogenic amino acid derivative featuring a tetrahydrothiophene (thiolane) ring, which serves as a critical chiral building block in advanced organic synthesis. Its unique structure, combining a constrained cyclic sulfide with both amino and carboxylic acid functional groups, makes it indispensable for constructing complex molecular architectures with precise stereochemistry. This compound is primarily sought after by research institutions and pharmaceutical companies engaged in the development of novel therapeutics, including protease inhibitors and other bioactive molecules.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of novel drug candidates, particularly in the development of protease inhibitors and enzyme modulators.
• Peptidomimetics Research: Used to introduce conformational constraints and sulfur-containing motifs into peptide backbones, enhancing stability and biological activity.
• Asymmetric Synthesis: Employed as a chiral auxiliary or starting material in stereoselective reactions to construct complex natural products and active pharmaceutical ingredients (APIs).
• Ligand and Catalyst Development: Serves as a precursor for chelating ligands in catalysis or as a scaffold for organocatalysts.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying enzyme function and biological pathways.
• Agrochemical Research: Investigated as a building block for novel crop protection agents with unique modes of action.

Basic Information

Product Name	(R)-3-Aminotetrahydrothiophene-3-Carboxylic Acid
CAS No.	1315054-23-9
Molecular Formula	C5H9NO2S
Molecular Weight	147.20 g/mol
Synonyms	(R)-3-Amino-3-carboxytetrahydrothiophene; (3R)-3-Aminotetrahydrothiophene-3-carboxylic acid; (R)-3-Amino-3-(carboxy)thiolane; (R)-3-Aminothiolane-3-carboxylic acid; (R)-Amino-THTC; (R)-ATTC; (R)-3-Amino-3-tetrahydrothiophenecarboxylic acid; (R)-3-Amino-3-thiolanecarboxylic acid
EINECS	Contact for details

Quality Control

Our (R)-3-Aminotetrahydrothiophene-3-Carboxylic Acid is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing to ensure high chemical purity and chiral integrity, which are critical for sensitive pharmaceutical applications. Standard testing includes chiral HPLC for enantiomeric excess determination, NMR for structural confirmation, and assays for purity and related substances. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. For long-term storage, consider using a desiccator or storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.