Description

1-Boc-3-Bromo-6-Fluoroindole is a high-purity, multi-functional indole derivative serving as a critical building block in advanced organic synthesis. Its value lies in the strategic placement of protecting (Boc) and reactive halogen (Br, F) groups, enabling precise, sequential functionalization for complex molecule construction. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for developing novel active pharmaceutical ingredients (APIs) and fine chemicals.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of complex drug candidates, especially those targeting central nervous system (CNS) disorders and oncology.
• Agrochemical Research: Used to construct novel heterocyclic scaffolds for the development of new herbicides, fungicides, and insecticides.
• Material Science: Building block for creating specialized organic electronic materials and functional polymers.
• Academic & R&D: A versatile reagent for methodological studies in cross-coupling reactions, palladium-catalyzed transformations, and indole chemistry.
• Peptide Mimetics: Employed in the design and synthesis of indole-based peptidomimetics and protease inhibitors.
• Fluorine Chemistry: The 6-fluoro substituent makes it a valuable substrate for studying fluorine's effects on bioactivity and physicochemical properties.

Basic Information

Product Name	1-Boc-3-Bromo-6-Fluoroindole
CAS No.	1314406-46-6
Molecular Formula	C₁₃H₁₃BrFNO₂
Molecular Weight	314.15 g/mol
Synonyms	1-(tert-Butoxycarbonyl)-3-bromo-6-fluoroindole; 3-Bromo-6-fluoro-1H-indole-1-carboxylic acid, 1,1-dimethylethyl ester; tert-Butyl 3-bromo-6-fluoro-1H-indole-1-carboxylate; 1-Boc-3-bromo-6-fluoro-1H-indole; Boc-3-Br-6-F-indole; N-Boc-3-bromo-6-fluoroindole; 3-Bromo-6-fluoroindole-1-carboxylic acid tert-butyl ester
EINECS	Contact for details

Quality Control

Our 1-Boc-3-Bromo-6-Fluoroindole is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all critical quality parameters. Our production adheres to cGMP principles where applicable, ensuring reliability for research and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.