Description

Lipoamide-Peg3-Mal CAS NO 1314378-19-2 is a heterobifunctional crosslinker featuring a lipoamide group and a maleimide (Mal) group connected by a triethylene glycol (PEG3) spacer. This compound is specifically engineered for the site-specific conjugation of biomolecules, leveraging the high reactivity of maleimide with thiols and the unique properties of the lipoamide moiety. It is an essential tool for researchers and developers in bioconjugation, pharmaceutical development, and advanced material science, enabling the creation of stable, well-defined protein-drug conjugates, antibody-drug conjugates (ADCs), and functionalized surfaces.

Application

• Antibody-Drug Conjugate (ADC) Linker: A critical component for constructing stable, cleavable, or non-cleavable linkages between cytotoxic payloads and monoclonal antibodies.
• Protein and Peptide Labeling: For site-specific attachment of fluorophores, biotin, or other probes to cysteine residues without disrupting native protein structure.
• Surface Functionalization: Modification of gold nanoparticles, biosensors, or chromatography matrices via the lipoamide group for thiol-gold chemistry or disulfide exchange.
• Polymer-Protein Conjugation: Creating PEGylated therapeutics with controlled stoichiometry and attachment sites to improve pharmacokinetics and reduce immunogenicity.
• Diagnostic Reagent Development: Synthesis of enzyme conjugates or hapten-carrier protein complexes for immunoassays and diagnostic kits.
• Stable Bioconjugate Research: Exploration of novel drug delivery systems and biomaterials where controlled release or specific targeting is required.

Basic Information

Product Name	Lipoamide-Peg3-Mal
CAS No.	1314378-19-2
Molecular Formula	C22H36N2O8S2
Molecular Weight	520.66 g/mol
Synonyms	6-Maleimidohexanoic acid (lipoyl-PEG3) amide; Lipoic acid-PEG3-maleimide; Maleimide-PEG3-Lipoamide; α-Lipoic acid-PEG3-MAL; 5-({2-[2-(2-{2-[(1,2-Dithiolan-3-yl)pentanoyl]amino}ethoxy)ethoxy]ethyl}amino)-5-oxopentanoic acid maleimide; N-(3-(2-(2-(3-(1,2-Dithiolan-3-yl)pentanamido)ethoxy)ethoxy)propyl)maleimide; Lipoamide-PEG3-Maleimide; Heterobifunctional PEG crosslinker Lipoamide-PEG3-Mal
EINECS	Contact for details

Quality Control

Our Lipoamide-Peg3-Mal is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements for research and pharmaceutical development. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing purity, identity, and impurity profiles as determined by HPLC, NMR, and MS. We support compliance with cGMP and ICH guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) in a dry, freezer. This product is hygroscopic (moisture-sensitive) and light-sensitive. Allow the vial to warm to room temperature in a desiccator before opening to prevent condensation and hydrolysis.

Specification

Item	Specification
Appearance	White to off-white solid or viscous oil
Identification (HPLC/MS)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF, acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.