Description

2-tert-Butoxycarbonylamino-4,5,6,7-Tetrahydro-Benzo[B]Thiophene-3-Carboxylic Acid Methyl Ester is a high-purity, advanced pharmaceutical intermediate crucial for modern drug discovery and development. This compound serves as a key building block in the synthesis of complex molecules, particularly those targeting central nervous system and metabolic disorders. It is primarily utilized by research institutions, contract research organizations (CROs), and pharmaceutical companies engaged in the development of novel therapeutic agents.

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of novel active pharmaceutical ingredients (APIs), especially for neurological and psychiatric drug candidates.
• Protease Inhibitor Research: Used in the development and screening of protease inhibitors due to its specific molecular scaffold.
• Chemical Biology & Medicinal Chemistry: Serves as a versatile scaffold for constructing focused libraries in structure-activity relationship (SAR) studies and hit-to-lead optimization.
• Peptidomimetic Synthesis: Employed in the design and synthesis of peptidomimetics, which are molecules that mimic the structure and function of peptides.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring high chemical fidelity.
• Academic Research: Used in university and institutional labs for fundamental research in organic synthesis methodologies and heterocyclic chemistry.

Basic Information

Product Name	2-tert-Butoxycarbonylamino-4,5,6,7-Tetrahydro-Benzo[B]Thiophene-3-Carboxylic Acid Methyl Ester
CAS No.	1313712-54-7
Molecular Formula	C16H23NO4S
Molecular Weight	325.42 g/mol
Synonyms	Methyl 2-((tert-butoxycarbonyl)amino)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate; 2-(Boc-amino)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylic acid methyl ester; Boc-Amino-Tetrahydrobenzothiophene Methyl Ester; 2-(tert-Butoxycarbonylamino)-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylic acid methyl ester; 2-((tert-Butoxycarbonyl)amino)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylic Acid Methyl Ester; 1313712-54-7; Boc-protected tetrahydrobenzothiophene derivative
EINECS	Contact for details

Quality Control

Our production of 2-tert-Butoxycarbonylamino-4,5,6,7-Tetrahydro-Benzo[B]Thiophene-3-Carboxylic Acid Methyl Ester adheres to stringent quality management protocols to ensure batch-to-batch consistency and high chemical purity suitable for research and development. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We support compliance with cGMP (current Good Manufacturing Practice) standards for advanced intermediates and can provide material for regulatory filings upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). The product is light-sensitive and should be handled and stored away from strong acids and organic solvents to maintain stability. Keep the container tightly sealed to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.