Description

n-Acetylneuraminic Acid-D3 is a stable isotope-labeled analog of N-acetylneuraminic acid, a fundamental sialic acid. This high-purity deuterated compound is essential for use as an internal standard in quantitative mass spectrometry-based analyses, ensuring unparalleled accuracy and reliability in measurement. It is a critical reagent for researchers and quality control laboratories in the pharmaceutical, biotechnology, and diagnostic sectors who require precise quantification of sialic acids in complex biological matrices.

Application

• Quantitative Mass Spectrometry (LC-MS/MS, GC-MS): Serves as a stable isotope-labeled internal standard for the accurate quantification of endogenous N-acetylneuraminic acid and related sialic acids in bioanalytical studies.
• Pharmaceutical R&D and Bioanalysis: Used in pharmacokinetic and metabolomic studies to track sialic acid metabolism, glycoprotein drug characterization, and biomarker discovery.
• Glycobiology Research: Enables precise measurement of sialic acid content in glycoproteins, glycolipids, and oligosaccharides, crucial for understanding cell signaling and disease mechanisms.
• Diagnostic Assay Development: Employed in the calibration and validation of clinical diagnostic tests that measure sialic acid levels, which can be indicators of certain cancers and inflammatory conditions.
• Quality Control in Biologics Manufacturing: Critical for monitoring and controlling the sialylation patterns of therapeutic proteins, such as monoclonal antibodies and enzymes, which directly impact drug efficacy and safety.
• Nutritional and Food Science Analysis: Applied in research to quantify sialic acids in nutritional supplements, infant formula, and functional foods.

Basic Information

Product Name	n-Acetylneuraminic Acid-D3
CAS No.	1312777-24-4
Molecular Formula	C11H16D3NO9
Molecular Weight	312.28 g/mol (for deuterated form)
Synonyms	Neu5Ac-D3; Sialic Acid-D3; N-Acetyl-D3-neuraminic Acid; 5-Acetamido-3,5-dideoxy-D-glycero-D-galacto-non-2-ulopyranosonic Acid-D3; Deuterated N-Acetylneuraminic Acid; Stable Isotope Labeled NANA; [acetyl-D3]-N-Acetylneuraminic Acid
EINECS	Contact for details

Quality Control

Our n-Acetylneuraminic Acid-D3 is manufactured under strict quality systems to ensure the high chemical and isotopic purity required for analytical applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing parameters such as isotopic enrichment (D3), chemical purity by HPLC, and identity confirmation. We adhere to relevant industry standards for fine chemicals and stable isotope-labeled compounds.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below. The product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain integrity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment (D3)	≥ 98 atom % D
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.