Description

1H-Pyrrolo[2,3-B]Pyridine-3-Carboxylic Acid, 2-(Bromomethyl)-5-Fluoro-1-(Phenylsulfonyl)-, Methyl Ester is a high-value, multi-functional heterocyclic building block designed for advanced synthetic chemistry. This compound is critical for researchers and process chemists developing novel active pharmaceutical ingredients (APIs) and agrochemicals, where its unique bromomethyl and fluorinated pyrrolopyridine scaffold enables precise molecular construction. Its primary value lies in serving as a key intermediate for the synthesis of complex molecules targeting kinase inhibition and other therapeutic areas, making it essential for pharmaceutical R&D and fine chemical manufacturing.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of kinase inhibitors and other small-molecule drug candidates.
• Agrochemical Research: Used in developing novel herbicides and pesticides leveraging its fluorinated heterocyclic structure.
• Chemical Biology: Serves as a probe or linker in medicinal chemistry for structure-activity relationship (SAR) studies.
• Material Science: Potential precursor for advanced organic electronic materials due to its conjugated system.
• Custom Synthesis: Employed by contract research and manufacturing organizations (CROs/CMOs) for client-specific molecule assembly.
• Academic Research: Used in university laboratories for methodological development in organic synthesis and heterocyclic chemistry.

Basic Information

Product Name	1H-Pyrrolo[2,3-B]Pyridine-3-Carboxylic Acid, 2-(Bromomethyl)-5-Fluoro-1-(Phenylsulfonyl)-, Methyl Ester
CAS No.	1312755-49-9
Molecular Formula	C₁₇H₁₄BrFN₂O₄S
Molecular Weight	441.27 g/mol
Synonyms	Methyl 2-(bromomethyl)-5-fluoro-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine-3-carboxylate; 1H-Pyrrolo[2,3-b]pyridine-3-carboxylic acid, 2-(bromomethyl)-5-fluoro-1-(phenylsulfonyl)-, methyl ester; 2-(Bromomethyl)-5-fluoro-1-tosyl-1H-pyrrolo[2,3-b]pyridine-3-carboxylic acid methyl ester; 1312755-49-9; 5-fluoro-2-(bromomethyl)-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine-3-carboxylic acid methyl ester
EINECS	Contact for details

Quality Control

Our production of 1H-Pyrrolo[2,3-B]Pyridine-3-Carboxylic Acid, 2-(Bromomethyl)-5-Fluoro-1-(Phenylsulfonyl)-, Methyl Ester adheres to stringent quality protocols to ensure batch-to-batch consistency and reliability for critical R&D and scale-up processes. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles, generated using validated analytical methods including HPLC, NMR, and MS. We operate under a cGMP-compliant quality management system, ensuring traceability and documentation suitable for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The compound is sensitive to strong acids and organic solvents; keep away from incompatible materials. For long-term storage, consider inert atmosphere conditions to maximize stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.