Description

1H-Pyrrolo[2,3-b]pyridine-3-carboxylic acid, 5-fluoro-2-methyl-, methyl ester is a high-purity, fluorinated heterocyclic building block of significant interest in advanced organic synthesis. This compound matters as a critical intermediate for constructing complex molecular architectures, particularly in pharmaceutical research and development. It is primarily needed by medicinal chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for the creation of novel active ingredients.

Application

• Pharmaceutical Intermediate: Serves as a key scaffold in the synthesis of potential drug candidates, especially kinase inhibitors and other targeted therapies.
• Medicinal Chemistry Research: Used extensively in hit-to-lead optimization and structure-activity relationship (SAR) studies due to its privileged pyrrolopyridine core.
• Agrochemical Development: Employed in the research and synthesis of novel herbicides, fungicides, or insecticides that utilize fluorinated heterocycles for enhanced activity.
• Chemical Biology Probes: Acts as a building block for creating fluorescent tags, enzyme inhibitors, or other molecular probes used in biochemical research.
• Material Science Precursor: Can be utilized in the development of organic electronic materials or advanced polymers requiring specific heterocyclic motifs.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of bespoke compounds for client projects.

Basic Information

Product Name	1H-Pyrrolo[2,3-b]pyridine-3-carboxylic acid, 5-fluoro-2-methyl-, methyl ester
CAS No.	1312755-47-7
Molecular Formula	C11H9FN2O2
Molecular Weight	220.20 g/mol
Synonyms	Methyl 5-fluoro-2-methyl-1H-pyrrolo[2,3-b]pyridine-3-carboxylate; 5-Fluoro-2-methyl-1H-pyrrolo[2,3-b]pyridine-3-carboxylic acid methyl ester; 1H-Pyrrolo[2,3-b]pyridine-3-carboxylic acid, 5-fluoro-2-methyl-, methyl ester; 5-Fluoro-2-methyl-1H-pyrrolo[2,3-b]pyridine-3-carboxylic acid methyl ester; Fluorinated pyrrolopyridine ester; 1312755-47-7; 5-Fluoro-2-methyl-pyrrolo[2,3-b]pyridine-3-carboxylic acid methyl ester
EINECS	Contact for details

Quality Control

Our 1H-Pyrrolo[2,3-b]pyridine-3-carboxylic acid, 5-fluoro-2-methyl-, methyl ester is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for research and development. All products undergo rigorous analytical testing, including HPLC, NMR, and MS, to verify identity and purity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment. We adhere to cGMP principles where applicable to support our clients' regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep the container tightly sealed to protect from moisture. Store away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.