Description

Rilpivirine-D6 CAS NO 1312424-26-2 is a deuterated isotopologue of the non-nucleoside reverse transcriptase inhibitor (NNRTI) Rilpivirine, where six hydrogen atoms are replaced by deuterium. This stable-labeled compound is an essential internal standard for the precise quantification of Rilpivirine in biological matrices using advanced analytical techniques like LC-MS/MS. It is a critical tool for pharmaceutical research and development, clinical pharmacology, and bioanalytical laboratories focused on antiretroviral drug development and therapeutic drug monitoring.

Application

• Bioanalytical Internal Standard: Primary use as a stable isotope-labeled internal standard for the accurate and precise quantification of Rilpivirine in plasma, serum, and other biological samples via LC-MS/MS.
• Pharmacokinetic (PK) and Pharmacodynamic (PD) Studies: Enables reliable measurement of drug concentration-time profiles, bioavailability, and metabolism studies in clinical and preclinical research.
• Drug Metabolism and Excretion Research: Used in ADME (Absorption, Distribution, Metabolism, and Excretion) studies to track and analyze the parent drug without interference from metabolites.
• Therapeutic Drug Monitoring (TDM): Supports the development and validation of robust assays for monitoring Rilpivirine levels in patients undergoing HIV treatment to ensure therapeutic efficacy and safety.
• Pharmaceutical Quality Control: Can be employed in method development and validation for the assay of Rilpivirine in active pharmaceutical ingredient (API) and finished dosage forms.
• Reference Material for Method Development: Serves as a critical reference compound for developing and validating new analytical methods in compliance with regulatory guidelines (FDA, EMA).

Basic Information

Product Name	Rilpivirine-D6
CAS No.	1312424-26-2
Molecular Formula	C22H12D6N6
Molecular Weight	Contact for details
Synonyms	4-[[4-[[4-[(E)-2-Cyanoethenyl]-2,6-dimethylphenyl]amino]pyrimidin-2-yl]amino]benzonitrile-d6; TMC278-D6; Edurant-D6; Rilpivirine (hexadeuterated); Rilpivirine-d6 (Internal Standard); RPV-D6; NNRTI Rilpivirine Deuterated Standard
EINECS	Contact for details

Quality Control

Our Rilpivirine-D6 is manufactured under strict quality systems to ensure the high chemical purity and isotopic enrichment required for sensitive bioanalytical applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing specifications for identity, purity (by HPLC), isotopic purity, and residual solvents. We adhere to relevant industry standards for reference materials to ensure reliable and reproducible performance in your analytical methods.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥98.0%
Isotopic Purity	≥98.0 atom % D
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH limits

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.