Description

n-Boc-4-(Hydroxymethyl)Isoindoline is a protected isoindoline derivative featuring both a tert-butoxycarbonyl (Boc) protecting group and a hydroxymethyl functional group. This compound is a crucial pharmaceutical intermediate and versatile organic building block for the synthesis of complex molecules. It is primarily utilized by research institutions and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors for developing new active ingredients and functional compounds.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and oncology targets.
• Peptidomimetic Chemistry: Used to incorporate constrained, rigid scaffolds into peptide analogs to enhance metabolic stability and bioavailability.
• Ligand and Catalyst Development: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis.
• Agrochemical Research: Intermediate in the development of novel herbicides, fungicides, and plant growth regulators.
• Material Science: Building block for creating functional polymers and organic electronic materials with specific optoelectronic properties.
• Chemical Biology: Used in the design and synthesis of molecular probes and tool compounds for biological target validation.

Basic Information

Product Name	n-Boc-4-(Hydroxymethyl)Isoindoline
CAS No.	1311254-56-4
Molecular Formula	C₁₄H₁₉NO₃
Molecular Weight	249.31 g/mol
Synonyms	tert-Butyl 4-(hydroxymethyl)isoindoline-2-carboxylate; 2-(tert-Butoxycarbonyl)-4-(hydroxymethyl)isoindoline; 4-(Hydroxymethyl)isoindoline-1-carboxylic acid tert-butyl ester; 1-Boc-4-(hydroxymethyl)isoindoline; Boc-4-(hydroxymethyl)isoindoline; 4-Hydroxymethyl-1,3-dihydro-2H-isoindole-2-carboxylic acid tert-butyl ester; 1,3-Dihydro-4-(hydroxymethyl)-2H-isoindole-2-carboxylic acid 1,1-dimethylethyl ester
EINECS	Contact for details

Quality Control

Our n-Boc-4-(Hydroxymethyl)Isoindoline is manufactured under a strict quality management system. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for critical research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); ensure the container is kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.