Description

Cyclobutane, 3-Bromo-1,1-Difluoro- is a specialized fluorinated and brominated cyclobutane derivative, serving as a high-value building block in advanced organic synthesis. Its unique structure, featuring both bromine and fluorine substituents on a strained four-membered ring, makes it a critical precursor for constructing complex molecules with tailored electronic and steric properties. This compound is essential for researchers and process chemists in the pharmaceutical and agrochemical industries, particularly for developing novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, especially those requiring fluorinated motifs to enhance metabolic stability, bioavailability, and membrane permeability.
• Agrochemical Synthesis: Used in the research and development of next-generation herbicides, fungicides, and pesticides, where the difluoro and bromo groups can impart unique biological activity.
• Material Science Research: Serves as a monomer or precursor for developing specialty polymers, liquid crystals, and advanced organic electronic materials.
• Cross-Coupling Reactions: The bromine atom acts as an excellent handle for versatile palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Negishi, Stille) to form new carbon-carbon bonds.
• Fluorination Chemistry: A valuable source of the difluoromethylene (CF2) group for introducing fluorine atoms into target molecules, a common strategy in modern medicinal chemistry.
• Chemical Biology Probes: Utilized in the creation of molecular probes and tags for studying biological systems and mechanisms of action.

Basic Information

Product Name	Cyclobutane, 3-Bromo-1,1-Difluoro-
CAS No.	1310729-91-9
Molecular Formula	C4H5BrF2
Molecular Weight	171.98 g/mol
Synonyms	3-Bromo-1,1-difluorocyclobutane; 1,1-Difluoro-3-bromocyclobutane; 3-Bromodifluorocyclobutane; (3-Bromocyclobutyl)difluoromethane; Cyclobutane, bromodifluoro-; Bromodifluorocyclobutane
EINECS	Contact for details

Quality Control

Our Cyclobutane, 3-Bromo-1,1-Difluoro- is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including GC, NMR, and HPLC, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) detailing purity, assay, and impurity profiles are provided with every shipment to support your R&D and scale-up activities.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Due to its highly volatile nature, ensure containers are properly sealed and stored upright. Keep away from strong bases and incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.