Description

1H-Indole-7-Carboxamide, 4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)- is a high-value, advanced pharmaceutical intermediate featuring a pinacol boronate ester functional group. This compound is critical for enabling Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology in modern medicinal chemistry for constructing complex carbon-carbon bonds. It is primarily sought after by research institutions and pharmaceutical companies engaged in the discovery and development of novel active pharmaceutical ingredients (APIs), particularly for oncology and central nervous system (CNS) targets.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of complex drug candidates, especially those containing indole scaffolds.
• Suzuki-Miyaura Cross-Coupling Reagent: The boronate ester group enables efficient palladium-catalyzed coupling with aryl or vinyl halides, facilitating the rapid assembly of biaryl structures.
• Medicinal Chemistry Research: Used in high-throughput screening and structure-activity relationship (SAR) studies to explore new chemical entities for therapeutic potential.
• Process Chemistry Development: Employed in the scale-up and optimization of synthetic routes for potential new drugs under Good Manufacturing Practice (GMP) guidelines.
• Chemical Biology Probes: Utilized in the creation of labeled compounds or molecular probes for studying biological pathways and target engagement.

Basic Information

Product Name	1H-Indole-7-Carboxamide, 4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-
CAS No.	1309980-17-3
Molecular Formula	C15H19BN2O3
Molecular Weight	286.14 g/mol
Synonyms	4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indole-7-carboxamide; 4-BPin-1H-indole-7-carboxamide; 7-Carbamoyl-4-indoleboronic acid pinacol ester; 4-(Pinacolatoboryl)-1H-indole-7-carboxamide; 1H-Indole-7-carboxamide, 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-; 1309980-17-3; 4-Borono-1H-indole-7-carboxamide pinacol ester
EINECS	Contact for details

Quality Control

Our 1H-Indole-7-Carboxamide, 4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)- is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the exacting standards required for pharmaceutical research and development. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage and when dispensing to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.