Description

6-Ethynyl-3,4-Dihydroisoquinolin-1(2H)-One is a high-purity, advanced pharmaceutical intermediate featuring a reactive ethynyl group fused to a dihydroisoquinolinone scaffold. This compound is of significant value for medicinal chemistry research and development, serving as a critical building block for the synthesis of novel bioactive molecules. It is primarily sought after by pharmaceutical R&D teams and fine chemical manufacturers engaged in developing new therapeutic agents, particularly in oncology and CNS drug discovery. The CAS number for this compound is 1309955-20-1.

Application

• Pharmaceutical Intermediate: A key synthon for constructing complex molecular architectures in drug discovery programs.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization for new drug candidates.
• Proteolysis Targeting Chimera (PROTAC) Development: Serves as a potential linker or warhead component in the design of targeted protein degraders.
• Kinase Inhibitor Synthesis: Employed in the preparation of potential kinase inhibitors due to the privileged isoquinolinone structure.
• Chemical Biology Probes: Utilized to develop tool compounds for studying biological pathways and target validation.
• Academic & Contract Research: Supplied to universities and CROs for exploratory synthetic chemistry and bioactivity screening.

Basic Information

Product Name	6-Ethynyl-3,4-Dihydroisoquinolin-1(2H)-One
CAS No.	1309955-20-1
Molecular Formula	C11H9NO
Molecular Weight	171.20 g/mol
Synonyms	6-Ethynyl-1,2,3,4-tetrahydroisoquinolin-1-one; 6-Ethynyl-3,4-dihydro-1(2H)-isoquinolinone; 1(2H)-Isoquinolinone, 6-ethynyl-3,4-dihydro-; 1309955-20-1; 6-Ethynyl-1,2,3,4-tetrahydroisoquinoline-1-one; 6-Ethynyl-3,4-dihydro-2H-isoquinolin-1-one
EINECS	Contact for details

Quality Control

Our 6-Ethynyl-3,4-Dihydroisoquinolin-1(2H)-One is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the high standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at a controlled room temperature (15-25°C) in a cool, dry, and well-ventilated place. Due to its sensitivity to light and oxidation, prolonged exposure to air and light should be avoided.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Related Substances (HPLC)	Individual impurity ≤ 1.0%
Total Impurities	≤ 3.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.