Description

n-Trityl Losartan-D4 is a high-purity, deuterium-labeled derivative of the trityl-protected Losartan intermediate. This compound serves as a critical internal standard and reference material in quantitative analytical methods, ensuring the accuracy and reliability of data. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical testing facilities specializing in method development, pharmacokinetic studies, and quality control for angiotensin II receptor antagonists.

Application

• Internal Standard for LC-MS/MS: Essential for the precise quantification of Losartan and its metabolites in complex biological matrices like plasma and urine.
• Pharmaceutical Reference Standard: Used in method validation, assay development, and ensuring compliance with regulatory guidelines (e.g., FDA, ICH) for drug substance analysis.
• Metabolite Tracing Studies: Facilitates research into the metabolic pathways and bioavailability of Losartan and related compounds.
• Stable Isotope Labeling: Employed in advanced research applications requiring isotope dilution mass spectrometry for highest accuracy.
• Quality Control & Impurity Profiling: Aids in the identification and quantification of process-related impurities in active pharmaceutical ingredient (API) manufacturing.

Basic Information

Product Name	n-Trityl Losartan-D4
CAS No.	1309283-24-6
Molecular Formula	C46H37D4ClN6O
Molecular Weight	717.31 g/mol
Synonyms	Losartan-d4 Trityl Ester; 2-Butyl-5-chloro-3-[[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl-d4]oxy]triphenylmethyl Losartan; Deuterated Trityl Losartan; Losartan (Trityl)-d4; 5-(4'-((2-Butyl-5-chloro-1H-imidazol-4-yl)methoxy-d4)-[1,1'-biphenyl]-2-yl)-1-trityl-1H-tetrazole; n-Trityl Losartan (tetradeuterated); Losartan-d4 Triphenylmethyl Ester
EINECS	Contact for details

Quality Control

Our n-Trityl Losartan-D4 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including NMR, HPLC, and mass spectrometry, to confirm chemical identity, isotopic purity (D4), and chemical purity. Certificates of Analysis (COA) detailing all test results are provided to ensure traceability and compliance with your research or quality standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D4)	≥ 98.0 atom % D
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.