Description

5-Bromo-4-Chloro-Thiophene-2-Sulfonyl Chloride is a high-value, multi-functional heterocyclic building block and key synthetic intermediate. Its core value proposition lies in its reactive sulfonyl chloride group, which enables efficient derivatization into sulfonamides and other functionalized thiophene compounds essential for advanced research and development. This compound is primarily needed by pharmaceutical, agrochemical, and material science industries for the synthesis of novel active ingredients and specialty chemicals.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for drugs targeting various therapeutic areas.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides, leveraging the thiophene scaffold for bioactivity.
• Material Science Research: Serves as a building block for creating functional polymers, organic semiconductors, and advanced materials with specific electronic properties.
• Chemical Biology & Proteomics: Acts as a reactive handle for bioconjugation and the development of chemical probes and activity-based protein profiling (ABPP) reagents.
• Sulfonamide Library Synthesis: The sulfonyl chloride moiety is ideal for high-throughput parallel synthesis to create diverse sulfonamide libraries for drug discovery screening.
• Ligand & Catalyst Development: Employed in the design and synthesis of novel ligands and organocatalysts for asymmetric synthesis.

Basic Information

Product Name	5-Bromo-4-Chloro-Thiophene-2-Sulfonyl Chloride
CAS No.	1307307-49-8
Molecular Formula	C4HBrCl2O2S2
Molecular Weight	306.00 g/mol
Synonyms	4-Chloro-5-bromothiophene-2-sulfonyl chloride; 2-Thiophenesulfonyl chloride, 5-bromo-4-chloro-; 5-Bromo-4-chloro-2-thiophenesulfonyl chloride; 5-Bromo-4-chlorothiophene-2-sulfonyl chloride; 4-Chloro-5-bromo-2-thiophenesulfonyl chloride; 1307307-49-8
EINECS	Contact for details

Quality Control

Our 5-Bromo-4-Chloro-Thiophene-2-Sulfonyl Chloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and IR spectroscopy, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all specifications and test results. Our quality commitment ensures the material meets the stringent requirements for research and process development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat, sparks, open flames, and incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.