Description

1-Boc-5-Bromo-6-Methyl-1H-Indazole is a high-purity, advanced pharmaceutical intermediate featuring a protected indazole core. This compound is a critical building block in modern medicinal chemistry, enabling the synthesis of complex molecules with targeted biological activity. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel therapeutic agents, including kinase inhibitors and other small-molecule drugs.

Application

• Pharmaceutical Intermediate: A key synthon for constructing complex indazole-based active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies for drug discovery programs.
• Kinase Inhibitor Synthesis: Serves as a core scaffold in the development of potent and selective kinase inhibitors for oncology and inflammatory diseases.
• Custom Synthesis: Employed in contract research and manufacturing (CRO/CMO) for the production of bespoke compounds and reference standards.
• Chemical Biology Probes: Useful for creating molecular probes to study enzyme function and cellular signaling pathways.

Basic Information

Product Name	1-Boc-5-Bromo-6-Methyl-1H-Indazole
CAS No.	1305320-67-5
Molecular Formula	C₁₃H₁₅BrN₂O₂
Molecular Weight	311.18 g/mol
Synonyms	1-(tert-Butoxycarbonyl)-5-bromo-6-methyl-1H-indazole; 5-Bromo-6-methyl-1H-indazole-1-carboxylic acid tert-butyl ester; tert-Butyl 5-bromo-6-methyl-1H-indazole-1-carboxylate; 1-Boc-5-bromo-6-methylindazole; Boc-5-Br-6-Me-indazole; 1305320-67-5
EINECS	Contact for details

Quality Control

Our 1-Boc-5-Bromo-6-Methyl-1H-Indazole is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided and available upon request to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). The product is moisture-sensitive; keep the container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥98.0%
Purity (HPLC)	≥98.5%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.