Description

1-Boc-4-Fluoro-1H-Indazole is a high-purity, protected indazole derivative serving as a critical building block in modern organic synthesis. Its value lies in providing a versatile, fluorinated scaffold for constructing complex molecules, particularly in pharmaceutical research and development. This compound is essential for medicinal chemists and process development scientists working in the discovery and scale-up of new active pharmaceutical ingredients (APIs) and agrochemicals.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, especially kinase inhibitors and other targeted therapies.
• Agrochemical Research: Used in the development of new pesticides and herbicides, leveraging the bioactivity of the fluorinated indazole core.
• Chemical Biology Probe Synthesis: Employed to create molecular tools for studying enzyme function and biological pathways.
• Material Science: Serves as a monomer or functionalizing agent in the development of advanced polymers and organic electronic materials.
• Custom Synthesis & Contract Manufacturing: A fundamental starting material for custom synthesis projects and scale-up campaigns under GMP or non-GMP conditions.

Basic Information

Product Name	1-Boc-4-Fluoro-1H-Indazole
CAS No.	1305320-65-3
Molecular Formula	C₁₂H₁₃FN₂O₂
Molecular Weight	236.24 g/mol
Synonyms	1-[(tert-Butoxy)carbonyl]-4-fluoro-1H-indazole; 4-Fluoro-1H-indazole-1-carboxylic acid tert-butyl ester; tert-Butyl 4-fluoro-1H-indazole-1-carboxylate; 1-Boc-4-fluoroindazole; Boc-4-fluoroindazole; 4-Fluoro-1-Boc-indazole; 1-(tert-Butoxycarbonyl)-4-fluoro-1H-indazole
EINECS	Contact for details

Quality Control

Our 1-Boc-4-Fluoro-1H-Indazole is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity, suitable for research and development applications. We provide comprehensive analytical data including HPLC, NMR, and mass spectrometry. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is available for every batch upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed and consideration should be given to storage under an inert atmosphere for long-term preservation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.