Description

1-Boc-5-Bromo-6-Methoxy-1H-Indazole is a high-purity, advanced pharmaceutical intermediate characterized by its protected indazole core structure. This compound is critical for medicinal chemistry research and development, serving as a versatile building block for the synthesis of complex bioactive molecules. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical and biotechnology industries for creating novel drug candidates, particularly in oncology and CNS therapeutic areas.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel small-molecule drug candidates targeting various disease pathways.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization for new therapeutic agents.
• Process Chemistry Development: Serves as a starting material or intermediate in the scale-up and optimization of API (Active Pharmaceutical Ingredient) manufacturing routes.
• Proteolysis Targeting Chimera (PROTAC) Development: Potential component in the linker or warhead sections of bifunctional degrader molecules.
• Kinase Inhibitor Synthesis: Precursor for the development of selective kinase inhibitors due to the indazole scaffold's prevalence in this drug class.
• Chemical Biology Probes: Used to create tool compounds for studying biological targets and cellular processes.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for client-specific synthesis projects.
• Academic Research: Utilized in university and institutional labs for exploratory synthetic chemistry and drug discovery programs.

Basic Information

Product Name	1-Boc-5-Bromo-6-Methoxy-1H-Indazole
CAS No.	1305320-56-2
Molecular Formula	C₁₃H₁₅BrN₂O₃
Molecular Weight	327.17 g/mol
Synonyms	1-Boc-5-bromo-6-methoxy-1H-indazole; 5-Bromo-6-methoxy-1H-indazole-1-carboxylic acid tert-butyl ester; tert-Butyl 5-bromo-6-methoxy-1H-indazole-1-carboxylate; 1-(tert-Butoxycarbonyl)-5-bromo-6-methoxy-1H-indazole; 5-Bromo-6-methoxyindazole-1-N-Boc; Boc-5-Br-6-MeO-indazole; 1H-Indazole-1-carboxylic acid, 5-bromo-6-methoxy-, 1,1-dimethylethyl ester
EINECS	Contact for details

Quality Control

Our 1-Boc-5-Bromo-6-Methoxy-1H-Indazole is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and MS, to ensure compliance with exacting standards for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing purity, impurities, and full analytical data is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The product is moisture-sensitive; keep the container tightly sealed under an inert atmosphere if possible. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.