Description

Methyl 1-((4-Bromothiophen-2-Yl)Methyl)Piperidine-4-Carboxylate CAS NO 1305046-45-0 is a high-purity, advanced pharmaceutical intermediate featuring a unique molecular scaffold combining piperidine and bromothiophene moieties. This compound is valued for its role as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and oncology research. It is essential for medicinal chemists and process development scientists in pharmaceutical R&D and fine chemical manufacturing seeking to develop new therapeutic candidates with targeted biological activity.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of potential drug candidates, especially for neurological disorders and cancer therapeutics.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization due to its versatile piperidine-thiophene core.
• Process Chemistry & Scale-up: Employed in the development and optimization of scalable synthetic routes for new chemical entities (NCEs).
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations specializing in custom synthesis and API development for client projects.
• Biochemical Tool Compound: Potential use in developing probes for biological target validation and assay development.
• Academic Research: Utilized in university and institutional labs for exploratory synthetic and pharmacological studies.

Basic Information

Product Name	Methyl 1-((4-Bromothiophen-2-Yl)Methyl)Piperidine-4-Carboxylate
CAS No.	1305046-45-0
Molecular Formula	C13H16BrNO2S
Molecular Weight	330.24 g/mol
Synonyms	Methyl 1-[(4-bromothiophen-2-yl)methyl]piperidine-4-carboxylate; 1-((4-Bromothiophen-2-yl)methyl)piperidine-4-carboxylic acid methyl ester; 4-Piperidinecarboxylic acid, 1-[(4-bromo-2-thienyl)methyl]-, methyl ester; Methyl 1-((4-bromo-2-thienyl)methyl)-4-piperidinecarboxylate; 1305046-45-0; Methyl 1-[(4-bromothiophen-2-yl)methyl]-4-piperidinecarboxylate
EINECS	Contact for details

Quality Control

Our Methyl 1-((4-Bromothiophen-2-Yl)Methyl)Piperidine-4-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment aligns with cGMP principles where applicable, supporting its use in regulated research and development pipelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep the container sealed to protect from moisture. For long-term storage, consider inert atmosphere conditions to ensure optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.