Description

(2S)-1-(1,1,1,2,3,3,3-Heptadeuteriopropan-2-Ylamino)-3-[4-(2-Methoxyethyl)Phenoxy]Propan-2-Ol is a deuterated analog of a β-adrenergic receptor antagonist, offering enhanced metabolic stability for advanced research and development. This high-purity compound is critical for pharmacokinetic and metabolic studies, providing a stable isotopic label for precise analytical tracking. It is primarily utilized by pharmaceutical R&D teams, contract research organizations (CROs), and academic institutions focused on cardiovascular drug discovery and development.

Application

• Pharmaceutical Reference Standard: Serves as a certified reference material (CRM) for analytical method development and validation in drug quality control.
• Metabolic Pathway Tracing: Used as a stable isotope-labeled internal standard in LC-MS/MS and GC-MS analyses to study drug metabolism and bioavailability.
• Preclinical Research: Employed in in vitro and in vivo studies to investigate the pharmacodynamics of β-blockers with improved isotopic properties.
• Deuterated Drug Synthesis: Acts as a key chiral intermediate or precursor in the synthesis of deuterium-enriched active pharmaceutical ingredients (APIs) for new chemical entities (NCEs).
• Biochemical Assay Development: Utilized in receptor binding assays and other high-throughput screening (HTS) platforms to assess compound activity and selectivity.

Basic Information

Product Name	(2S)-1-(1,1,1,2,3,3,3-Heptadeuteriopropan-2-Ylamino)-3-[4-(2-Methoxyethyl)Phenoxy]Propan-2-Ol
CAS No.	1292906-91-2
Molecular Formula	C15H17D7NO3
Molecular Weight	284.40 g/mol
Synonyms	Deuterated Metoprolol-d7; (S)-Metoprolol-d7; (2S)-1-[4-(2-Methoxyethyl)phenoxy]-3-[(1,1,1,2,3,3,3-heptadeuterio-2-propanyl)amino]-2-propanol; Lopressor-d7; Betaloc-d7; 1-(Isopropylamino)-3-[4-(2-methoxyethyl)phenoxy]-2-propanol-d7; (S)-1-(Isopropylamino)-3-[p-(2-methoxyethyl)phenoxy]-2-propanol-d7
EINECS	Contact for details

Quality Control

Our deuterated compounds are manufactured under strict quality management systems. Each batch of (2S)-1-(1,1,1,2,3,3,3-Heptadeuteriopropan-2-Ylamino)-3-[4-(2-Methoxyethyl)Phenoxy]Propan-2-Ol undergoes rigorous analytical testing, including NMR, HPLC, and MS, to ensure chemical identity, isotopic purity, and chromatographic purity meet exacting standards. Certificates of Analysis (COA) detailing batch-specific results are provided and traceable to relevant in-house standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept in a desiccated environment to prevent moisture uptake, which can affect stability and purity. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (MS)	≥ 98.0 atom % D
Chemical Purity (Titration)	≥ 97.0%
Residual Solvents (GC)	Complies with ICH guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.