Description

tert-Butyl (5-Amino-1H-Indol-1-Yl)Acetate is a high-purity, protected indole derivative that serves as a critical synthetic intermediate in advanced organic synthesis. Its value lies in providing a versatile, reactive amine handle for constructing complex molecules, particularly in pharmaceutical research and development. This compound is essential for medicinal chemists and process development scientists working in the fields of drug discovery, agrochemicals, and specialty chemical manufacturing.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, particularly those targeting neurological and oncological pathways.
• Agrochemical Synthesis: Used in the research and development of new pesticides and herbicides, leveraging the indole scaffold's bioactivity.
• Peptidomimetics & Bioconjugation: Serves as a protected amino acid analog for constructing peptide-like molecules and for bioconjugation strategies.
• Material Science Research: Employed in the synthesis of organic semiconductors, dyes, and fluorescent markers due to the indole chromophore.
• Chemical Biology Probes: Acts as a precursor for developing molecular probes to study enzyme function and biological pathways.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) producing specialized compounds for clients.

Basic Information

Product Name	tert-Butyl (5-Amino-1H-Indol-1-Yl)Acetate
CAS No.	1292835-87-0
Molecular Formula	C₁₄H₁₈N₂O₂
Molecular Weight	246.31 g/mol
Synonyms	1H-Indole-1-acetic acid, 5-amino-, 1,1-dimethylethyl ester; 5-Amino-1H-indol-1-yl-acetic acid tert-butyl ester; tert-Butyl 2-(5-amino-1H-indol-1-yl)acetate; (5-Amino-1H-indol-1-yl)acetic acid tert-butyl ester; tert-Butyl (5-aminoindol-1-yl)acetate; 1-(tert-Butoxycarbonylmethyl)-5-aminoindole; 5-Amino-1-carboxymethylindole tert-butyl ester
EINECS	Contact for details

Quality Control

Every batch of tert-Butyl (5-Amino-1H-Indol-1-Yl)Acetate is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for research and development applications. A detailed Certificate of Analysis (COA) including purity (HPLC), identity confirmation (NMR, IR), and impurity profile is supplied with each shipment to guarantee consistency and traceability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption, which may affect stability and reactivity. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.