Description

Methyl 4-(4-Chlorophenyl)-3-(Chlorosulfonyl)-Thiophene-2-Carboxylate is a high-value, multi-functional heterocyclic building block and synthetic intermediate. This compound matters for its role as a versatile precursor in the development of advanced active pharmaceutical ingredients (APIs) and agrochemicals, enabling complex molecular transformations. It is primarily needed by research and development chemists, process development scientists, and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries for creating novel compounds with targeted biological activity.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, particularly in medicinal chemistry programs targeting various therapeutic areas.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides, herbicides, and fungicides due to its reactive chlorosulfonyl and ester functional groups.
• Material Science Research: Serves as a monomer or precursor for developing specialized polymers and organic electronic materials with unique properties.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes for studying biological pathways and enzyme functions.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving global clients.
• Academic & Industrial R&D: Essential for exploratory chemistry in academic institutions and corporate R&D centers focused on heterocyclic chemistry and sulfonamide derivatives.

Basic Information

Product Name	Methyl 4-(4-Chlorophenyl)-3-(Chlorosulfonyl)-Thiophene-2-Carboxylate
CAS No.	1291486-73-1
Molecular Formula	C12H8Cl2O4S2
Molecular Weight	351.22 g/mol
Synonyms	Methyl 3-(Chlorosulfonyl)-4-(4-chlorophenyl)thiophene-2-carboxylate; 4-(4-Chlorophenyl)-3-(chlorosulfonyl)thiophene-2-carboxylic acid methyl ester; 2-Thiophenecarboxylic acid, 4-(4-chlorophenyl)-3-(chlorosulfonyl)-, methyl ester; Methyl 4-(p-chlorophenyl)-3-(chlorosulfonyl)thiophene-2-carboxylate
EINECS	Contact for details

Quality Control

Our Methyl 4-(4-Chlorophenyl)-3-(Chlorosulfonyl)-Thiophene-2-Carboxylate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high purity and consistent chemical identity. Certificates of Analysis (COA) detailing all specifications are provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. Keep away from incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.