Description

7-Bromo-2-Methylisoquinolin-1(2H)-One CAS NO 1290634-35-3 is a high-purity brominated isoquinolinone derivative, serving as a critical synthetic intermediate in advanced organic chemistry. Its value lies in providing a versatile halogenated scaffold for constructing complex molecular architectures, particularly in pharmaceutical research and development. This compound is essential for medicinal chemists and process R&D teams in the pharmaceutical, agrochemical, and specialty chemical industries who require reliable building blocks for drug discovery and fine chemical synthesis.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in the development of kinase inhibitors and other small molecule therapeutics.
• Agrochemical Research: Used in the discovery and synthesis of new crop protection agents and herbicides, leveraging its halogenated heterocyclic structure.
• Material Science Precursor: Serves as a monomer or functional unit in the development of advanced organic electronic materials and specialty polymers.
• Chemical Biology Probe Development: Utilized as a core scaffold for creating tool compounds and molecular probes to study biological pathways and protein function.
• Cross-Coupling Reactions: The bromine atom makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck, Sonogashira) to form new carbon-carbon bonds.
• Library Synthesis for High-Throughput Screening: Employed in combinatorial chemistry to generate diverse compound libraries for biological activity screening.

Basic Information

Product Name	7-Bromo-2-Methylisoquinolin-1(2H)-One
CAS No.	1290634-35-3
Molecular Formula	C10H8BrNO
Molecular Weight	238.08 g/mol
Synonyms	7-Bromo-2-methyl-1,2-dihydroisoquinolin-1-one; 7-Bromo-2-methyl-1H-isoquinolin-1-one; 7-Bromo-2-methylisoquinolin-1(2H)-one; 2-Methyl-7-bromo-1(2H)-isoquinolinone; 1(2H)-Isoquinolinone, 7-bromo-2-methyl-; 7-Bromo-2-methyl-1,2-dihydroisoquinoline-1-one
EINECS	Contact for details

Quality Control

Our 7-Bromo-2-Methylisoquinolin-1(2H)-One is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) detailing batch-specific results are available upon request to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from incompatible materials. For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.