Description

5,7-Dichloro-1,2,3,4-Tetrahydroisoquinoline-6-Carboxylic Acid is a high-purity, synthetically valuable heterocyclic building block primarily used in advanced pharmaceutical research and development. This compound serves as a critical intermediate in the synthesis of complex molecules, particularly those targeting neurological and cardiovascular pathways. It is essential for medicinal chemists and process development scientists in the pharmaceutical, biotechnology, and fine chemical industries who require reliable, high-quality raw materials for API synthesis.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of novel active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and cardiovascular drugs.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization campaigns to develop new therapeutic candidates.
• Process Chemistry & Scale-up: Serves as a starting material or intermediate in the pilot and commercial-scale synthesis of complex drug molecules.
• Bioconjugation & Probe Development: The carboxylic acid functionality allows for conjugation, making it useful in creating biochemical probes and labeled compounds for diagnostic research.
• Fine Chemical Synthesis: Employed in the custom synthesis of specialized isoquinoline derivatives for various high-value chemical applications.

Basic Information

Product Name	5,7-Dichloro-1,2,3,4-Tetrahydroisoquinoline-6-Carboxylic Acid
CAS No.	1290176-71-4
Molecular Formula	C10H9Cl2NO2
Molecular Weight	246.09 g/mol
Synonyms	6-Carboxy-5,7-dichloro-1,2,3,4-tetrahydroisoquinoline; 5,7-Dichloro-6-carboxy-1,2,3,4-tetrahydroisoquinoline; 1,2,3,4-Tetrahydro-5,7-dichloroisoquinoline-6-carboxylic Acid; 5,7-Dichloro-THIQ-6-carboxylic Acid; 1290176-71-4; 5,7-Dichloro-1,2,3,4-tetrahydro-6-isoquinolinecarboxylic acid
EINECS	Contact for details

Quality Control

Our 5,7-Dichloro-1,2,3,4-Tetrahydroisoquinoline-6-Carboxylic Acid is manufactured under a strict quality management system. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, documenting all critical quality attributes. Our production can adhere to cGMP standards for pharmaceutical applications upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.