Description

(-)-Huperzine A-D6 is a deuterium-labeled analog of the naturally occurring alkaloid Huperzine A, specifically designed for use as an internal standard in quantitative analytical methods. This high-purity, stable-labeled compound is essential for ensuring accuracy and reliability in mass spectrometry-based analyses, particularly in pharmacokinetic and metabolic studies. It is a critical tool for researchers and quality control laboratories in the pharmaceutical, biotechnology, and academic sectors who require precise quantification of Huperzine A.

Application

• Internal Standard for LC-MS/MS: Primary use as a quantitative internal standard in Liquid Chromatography-Tandem Mass Spectrometry for the accurate measurement of Huperzine A in complex biological matrices.
• Pharmacokinetic Research: Enables precise tracking of drug absorption, distribution, metabolism, and excretion (ADME) in preclinical and clinical studies.
• Bioanalytical Method Development: Serves as a critical reference compound for developing and validating robust analytical methods compliant with GLP and FDA guidelines.
• Metabolite Identification: Aids in the identification and quantification of Huperzine A metabolites in in vitro and in vivo studies.
• Quality Control & Assurance: Used in pharmaceutical QC labs to ensure the potency and purity of Huperzine A active pharmaceutical ingredients (APIs) and finished dosage forms.
• Neuroscience Research: Supports investigative studies on acetylcholinesterase inhibition and potential applications in cognitive disorders.

Basic Information

Product Name	(-)-Huperzine A-D6
CAS No.	1290113-17-5
Molecular Formula	C15H12D6N2O
Molecular Weight	248.34 g/mol
Synonyms	Huperzine A-d6; (5R,9R,11E)-5-Amino-11-ethylidene-5,6,9,10-tetrahydro-7-methyl-5,9-methanocycloocta[b]pyridin-2(1H)-one-d6; Deuterated Huperzine A; [2H6]-Huperzine A; Selenagine A-d6; (-)-HupA-D6; Huperzine A Internal Standard; Huperzine A (methyl-d3, ethyl-d3)
EINECS	Contact for details

Quality Control

Every batch of (-)-Huperzine A-D6 is manufactured and analyzed under strict quality systems. We provide comprehensive analytical data to support your regulatory submissions and ensure traceability. A detailed Certificate of Analysis (COA) is supplied with each shipment, reporting critical parameters including isotopic purity, chemical purity, and residual solvent content. Our quality commitment aligns with the standards required for GMP and GLP environments.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, cool place. This product is hygroscopic (moisture-sensitive). For long-term storage, consider storage under an inert atmosphere. Allow the vial to warm to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (H-NMR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity	≥ 98.0 atom % D
Chemical Purity	≥ 95.0%
Residual Solvents (GC)	Meets ICH guidelines
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.