Description

5,7-Dichloro-1,2,3,4-Tetrahydroisoquinoline-6-Carboxylic Acid Hydrochloride is a high-purity, advanced pharmaceutical intermediate of significant importance in modern medicinal chemistry. This compound serves as a critical building block for the synthesis of complex molecules, particularly in the development of new therapeutic agents. It is primarily sought after by research institutions and pharmaceutical companies engaged in drug discovery and process chemistry.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel active pharmaceutical ingredients (APIs), especially those targeting the central nervous system.
• Medicinal Chemistry Research: Used as a versatile scaffold for constructing compound libraries in high-throughput screening and structure-activity relationship (SAR) studies.
• Process Development: Employed in the scale-up and optimization of synthetic routes for candidate drugs during clinical development phases.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the cGMP production of investigational and commercial drugs.
• Academic Research: Utilized in university and institutional labs for fundamental research in organic synthesis and heterocyclic chemistry.

Basic Information

Product Name	5,7-Dichloro-1,2,3,4-Tetrahydroisoquinoline-6-Carboxylic Acid Hydrochloride
CAS No.	1289646-93-0
Molecular Formula	C10H10Cl3NO2 • HCl
Molecular Weight	308.96 g/mol (Free base: 272.55 g/mol)
Synonyms	6-Carboxy-5,7-dichloro-1,2,3,4-tetrahydroisoquinoline hydrochloride; 5,7-Dichloro-6-carboxy-1,2,3,4-tetrahydroisoquinoline HCl; 1,2,3,4-Tetrahydro-5,7-dichloroisoquinoline-6-carboxylic acid hydrochloride; THIQ-6-COOH derivative; DCTIQCA-HCl
EINECS	Contact for details

Quality Control

Our 5,7-Dichloro-1,2,3,4-Tetrahydroisoquinoline-6-Carboxylic Acid Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for pharmaceutical R&D and manufacturing. Certificates of Analysis (COA) with full traceability are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.