Description

2-(1-Butyn-1-Yl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane is a high-value organoboron building block, specifically a pinacol-protected butynyl boronic ester, essential for modern synthetic chemistry. This compound matters because it enables precise carbon-carbon bond formation via Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology for constructing complex molecules in pharmaceutical and advanced material research. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and organic electronics industries for synthesizing novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, particularly those requiring alkyne-substituted aromatic or heteroaromatic systems.
• Agrochemical Synthesis: Used in creating novel herbicides, fungicides, and insecticides with tailored properties through cross-coupling chemistry.
• Material Science: Enables the construction of conjugated organic molecules for use in organic light-emitting diodes (OLEDs), organic photovoltaics (OPVs), and other electronic materials.
• Chemical Biology & Proteomics: Serves as a precursor for bioconjugation reagents and probes utilizing click chemistry (e.g., copper-catalyzed azide-alkyne cycloaddition) after deprotection.
• Ligand & Catalyst Development: Employed in the preparation of specialized phosphine or N-heterocyclic carbene ligands that incorporate alkyne functionalities.
• Academic & Industrial R&D: A versatile reagent for methodological development and exploring new synthetic pathways in organic chemistry laboratories worldwide.

Basic Information

Item	Detail
Product Name	2-(1-Butyn-1-Yl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane
CAS No.	1287752-88-8
Molecular Formula	C₁₀H₁₇BO₂
Molecular Weight	180.05 g/mol
Synonyms	1-Butyn-1-ylboronic acid pinacol ester; But-1-yn-1-ylboronic acid pinacol ester; 1-Butynylboronic acid pinacol ester; Pinacol (1-butyn-1-yl)boronate; 2-(But-1-yn-1-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 1-Butyne-1-boronic acid pinacol ester
EINECS	Contact for details

Quality Control

Every batch of our 2-(1-Butyn-1-Yl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane undergoes rigorous analytical testing to ensure it meets the high-purity standards required for sensitive cross-coupling reactions. We employ advanced techniques including GC, HPLC, and NMR spectroscopy to verify identity, purity, and the absence of critical impurities. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic (moisture-sensitive) nature, the container should be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to maintain product integrity. Recommended long-term storage temperature is 2-8°C.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.