Description

Propargyl-Peg5-Br is a bifunctional polyethylene glycol (PEG) derivative featuring a propargyl group and a bromine terminus, enabling orthogonal click chemistry and nucleophilic substitution reactions. This compound is essential for creating custom, water-soluble linkers and spacers in bioconjugation and materials science. It is primarily utilized by researchers and manufacturers in pharmaceutical development, biotech, and advanced polymer synthesis for constructing complex molecular architectures.

Application

• Bioconjugation Linker: Serves as a versatile spacer for attaching drugs, dyes, or targeting ligands to antibodies, proteins, or nanoparticles via copper-catalyzed azide-alkyne cycloaddition (CuAAC).
• Polymer & Dendrimer Synthesis: Acts as a functional monomer or cross-linking agent for creating PEG-based hydrogels, smart materials, and branched macromolecular structures.
• Proteomics & Diagnostics: Used to develop probes and assay components where water solubility and controlled functionalization are critical.
• Surface Functionalization: Enables the modification of surfaces (e.g., chips, beads) with alkynes for subsequent immobilization of biomolecules.
• ADC (Antibody-Drug Conjugate) Development: Provides a cleavable or non-cleavable PEGylated linker to optimize the pharmacokinetics and stability of therapeutic conjugates.
• Chemical Biology Tool: Facilitates the study of biomolecular interactions and cellular processes through site-specific labeling.

Basic Information

Product Name	Propargyl-Peg5-Br
CAS No.	1287660-83-6
Molecular Formula	C18H33BrO6
Molecular Weight	425.36 g/mol
Synonyms	1-Bromo-3,6,9,12,15-pentaoxaheptadec-16-yn-17-ol; Propargyl-PEG5-bromide; 2-(2-(2-(2-(2-(Prop-2-yn-1-yloxy)ethoxy)ethoxy)ethoxy)ethoxy)ethyl bromide; Bromo-PEG5-propargyl; Propargyl-PEG5-Br; Propargyl PEG5 Bromide; 16-Bromo-3,6,9,12,15-pentaoxaheptadec-1-yne; Bromo-PEG5-alkyne
EINECS	Contact for details

Quality Control

Our Propargyl-Peg5-Br is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR for structural confirmation, and mass spectrometry for identity verification. Certificates of Analysis (COA) detailing purity, assay, and impurity profiles are available upon request to ensure compliance with your research and production specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. The product is light-sensitive and should be handled under inert atmosphere when appropriate for long-term stability. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.