Description

5-[2-(Benzenesulfonyl)Ethyl]-3-[[(2R)-1-(Trideuteriomethyl)Pyrrolidin-2-Yl]Methyl]-1H-Indole is a sophisticated deuterated indole derivative of significant interest in advanced pharmaceutical research and development. This compound serves as a critical building block or intermediate for creating novel therapeutic agents, particularly where metabolic stability and pharmacokinetic profiling are paramount. It is primarily utilized by pharmaceutical R&D organizations, contract research organizations (CROs), and fine chemical manufacturers engaged in the synthesis of deuterium-labeled drug candidates and other high-value specialty chemicals.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of deuterated drug candidates for improved metabolic stability and extended half-life.
• Metabolic Tracer Development: Used in the creation of labeled compounds for drug metabolism and pharmacokinetics (DMPK) studies.
• Medicinal Chemistry Research: Serves as a versatile scaffold for structure-activity relationship (SAR) exploration in new therapeutic areas.
• Reference Standard: Acts as an analytical standard for quality control and method validation in API manufacturing.
• Biochemical Probe Synthesis: Employed in the development of chemical probes for target identification and validation in biological systems.
• Isotope-Labeled Compound Production: Essential for manufacturing deuterium-labeled materials used in mass spectrometry and NMR spectroscopy.

Basic Information

Product Name	5-[2-(Benzenesulfonyl)Ethyl]-3-[[(2R)-1-(Trideuteriomethyl)Pyrrolidin-2-Yl]Methyl]-1H-Indole
CAS No.	1287040-94-1
Molecular Formula	C22H25D3N2O2S
Molecular Weight	387.55 g/mol
Synonyms	5-[2-(Phenylsulfonyl)ethyl]-3-[[(2R)-1-(trideuteriomethyl)-2-pyrrolidinyl]methyl]-1H-indole; (R)-5-[2-(Benzenesulfonyl)ethyl]-3-[(1-(trideuteriomethyl)pyrrolidin-2-yl)methyl]-1H-indole; Deuterated Indole Sulfonamide Derivative; 1287040-94-1; 5-[2-(Benzenesulfonyl)ethyl]-3-{[(2R)-1-(trideuteriomethyl)pyrrolidin-2-yl]methyl}-1H-indole
EINECS	Contact for details

Quality Control

Our 5-[2-(Benzenesulfonyl)Ethyl]-3-[[(2R)-1-(Trideuteriomethyl)Pyrrolidin-2-Yl]Methyl]-1H-Indole is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and chiral purity analysis, to ensure it meets the exacting standards required for pharmaceutical R&D. Certificates of Analysis (COA) with detailed chromatographic data are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment. For long-term storage, consider using desiccants or storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Deuterium Incorporation (MS)	≥ 98 atom % D
Residual Solvents (GC)	Meets ICH Q3C guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.