Description

(R)-2-Hydroxy-4-Phenylbutyric Acid-D5 is a high-purity, deuterium-labeled chiral building block of significant importance in advanced pharmaceutical research and development. Its core value lies in its utility as a stable isotope-labeled internal standard, enabling precise quantification and metabolic studies in complex biological matrices. This compound is essential for researchers and manufacturers in the pharmaceutical industry, particularly those developing and analyzing active pharmaceutical ingredients (APIs) and metabolites.

Application

• As a deuterated internal standard for the accurate quantification of its non-labeled counterpart in bioanalytical methods using LC-MS/MS.
• In pharmacokinetic and metabolic studies to track drug absorption, distribution, metabolism, and excretion (ADME).
• For the synthesis of deuterium-labeled pharmaceutical intermediates, potentially used in the development of new chemical entities.
• In proteomics and metabolomics research as a tool for precise mass spectrometry-based analysis.
• As a reference material in quality control laboratories to ensure the accuracy and reliability of analytical results for related APIs.

Basic Information

Product Name	(R)-2-Hydroxy-4-Phenylbutyric Acid-D5
CAS No.	1286987-57-2
Molecular Formula	C10H7D5O3
Molecular Weight	~185.23 g/mol
Synonyms	(R)-2-Hydroxy-4-phenylbutanoic-2,3,3,4,4-d5 acid; (R)-HPA-D5; (R)-2-Hydroxy-4-phenylbutyric-2,3,3,4,4-d5 acid; (R)-HPBA-D5; (R)-Oxy-4-phenylbutyric Acid-D5; (R)-2-Hydroxy-4-phenylbutanoic Acid (phenyl-d5); (R)-2-Hydroxy-4-(phenyl-d5)butyric Acid
EINECS	Contact for details

Quality Control

Our (R)-2-Hydroxy-4-Phenylbutyric Acid-D5 is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity and isotopic enrichment verification, to ensure it meets the stringent requirements for research and development. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and isotopic purity is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% ee
Isotopic Purity (MS)	≥98 atom % D
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.