Description

1-Methyl-5-Nitro-1H-Benzimidazole-2-Butanoic Acid Ethyl Ester-D3 is a deuterated derivative of a benzimidazole-based compound, serving as a critical stable isotope-labeled intermediate. Its primary value lies in enabling advanced research and development in pharmacokinetics and metabolic studies, where precise tracing is essential. This high-purity compound is specifically needed by pharmaceutical R&D laboratories and contract research organizations (CROs) focused on developing and analyzing novel therapeutic agents.

Application

• Pharmaceutical Reference Standard: Used as an internal standard in quantitative LC-MS/MS analysis for accurate drug concentration measurement.
• Metabolic Pathway Tracing: Employed in ADME (Absorption, Distribution, Metabolism, Excretion) studies to track the fate of parent drug molecules in biological systems.
• Deuterated Drug Synthesis: Acts as a key building block in the synthesis of deuterium-labeled active pharmaceutical ingredients (APIs) for enhanced metabolic stability.
• Biomedical Research: Utilized in proteomics and biomarker discovery research where isotope labeling is required for precise quantification.
• Regulatory Submissions: Supports the development of validated analytical methods required for regulatory filings with agencies like the FDA and EMA.

Basic Information

Product Name	1-Methyl-5-Nitro-1H-Benzimidazole-2-Butanoic Acid Ethyl Ester-D3
CAS No.	1286893-94-4
Molecular Formula	C₁₄H₁₄D₃N₃O₄
Molecular Weight	Approx. 292.30 g/mol
Synonyms	Ethyl 1-Methyl-5-nitro-1H-benzimidazole-2-butanoate-d3; 1-Methyl-5-nitro-1H-benzimidazole-2-butanoic acid ethyl ester (deuterated); Deuterated Benzimidazole Ester; 2-Butanoic acid, 1-methyl-5-nitro-1H-benzimidazole-, ethyl ester-d3; Ethyl 4-(1-methyl-5-nitro-1H-benzimidazol-2-yl)butanoate-d3; Stable Isotope Labeled Benzimidazole Derivative; D3-Labeled Pharmaceutical Intermediate
EINECS	Contact for details

Quality Control

Our deuterated compounds are manufactured under strict quality systems to ensure isotopic purity and chemical integrity, critical for research accuracy. Each batch is analyzed using advanced techniques including NMR and Mass Spectrometry to confirm deuterium incorporation and chemical purity. A comprehensive Certificate of Analysis (COA) is provided, detailing assay, isotopic purity, and impurity profiles. We adhere to cGMP principles where applicable to support our clients' regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	Yellow to light brown solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (NMR/MS)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.