Description

(1-((2-(Trimethylsilyl)Ethoxy)Methyl)-1H-Pyrrolo[2,3-B]Pyridin-2-Yl)Boronic Acid is a high-purity, advanced pharmaceutical intermediate featuring a protected pyrrolopyridine boronic acid ester. This compound is specifically engineered for use in Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology in modern medicinal chemistry for constructing complex biaryl structures. It is an essential building block for research and development chemists in the pharmaceutical and agrochemical industries, particularly for the synthesis of novel active pharmaceutical ingredients (APIs) and drug candidates.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug molecules, especially kinase inhibitors and other targeted therapies.
• Suzuki-Miyaura Cross-Coupling: Serves as a versatile boronic acid ester coupling partner for the formation of carbon-carbon bonds between aromatic rings.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to develop new therapeutic agents.
• Agrochemical Synthesis: Employed in the research and development of novel pesticides and herbicides.
• Material Science: Potential building block for creating organic electronic materials and functional polymers.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations specializing in custom synthesis and process development.

Basic Information

Item	Detail
Product Name	(1-((2-(Trimethylsilyl)Ethoxy)Methyl)-1H-Pyrrolo[2,3-B]Pyridin-2-Yl)Boronic Acid
CAS No.	1286776-82-6
Molecular Formula	C14H23BN2O3Si
Molecular Weight	306.25 g/mol
Synonyms	1-((2-(Trimethylsilyl)ethoxy)methyl)-1H-pyrrolo[2,3-b]pyridine-2-boronic acid; 1H-Pyrrolo[2,3-b]pyridine-2-boronic acid, 1-[[2-(trimethylsilyl)ethoxy]methyl]-; 1-((2-(Trimethylsilyl)ethoxy)methyl)-1H-pyrrolo[2,3-b]pyridine-2-boronic acid; SEM-Protected Pyrrolopyridine Boronic Acid; 1-(SEM)-1H-Pyrrolo[2,3-b]pyridin-2-ylboronic Acid; 1286776-82-6; (1-(SEM)-1H-Pyrrolo[2,3-b]pyridin-2-yl)boronic Acid
EINECS	Contact for details

Quality Control

Our (1-((2-(Trimethylsilyl)Ethoxy)Methyl)-1H-Pyrrolo[2,3-B]Pyridin-2-Yl)Boronic Acid is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for research and development applications. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when possible to maintain stability and purity. Keep the container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥95% (Area %)
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.