Description

Rac Pholedrine-D3 is a deuterium-labeled isotopologue of the adrenergic agent pholedrine, specifically designed for use as an internal standard in analytical chemistry. This high-purity reference material is essential for ensuring the accuracy and reliability of quantitative analyses, particularly in complex biological matrices. It is primarily utilized by pharmaceutical researchers, forensic toxicologists, and contract research organizations (CROs) engaged in method development, pharmacokinetic studies, and quality control for drug metabolism and stability testing.

Application

• Internal Standard for LC-MS/MS: Critical for the precise quantification of pholedrine and related compounds in bioanalytical assays, correcting for matrix effects and instrument variability.
• Pharmaceutical Research & Development: Used in drug metabolism and pharmacokinetics (DMPK) studies to track the absorption, distribution, metabolism, and excretion (ADME) of the parent compound.
• Forensic and Clinical Toxicology: Enables accurate measurement of pholedrine in biological samples for diagnostic or legal purposes.
• Stability-Indicating Method Development: Serves as a stable reference point in assays designed to monitor drug degradation and impurity profiling.
• Metabolite Identification Studies: Aids in distinguishing drug-derived metabolites from endogenous compounds in mass spectrometry-based workflows.
• Quality Control & Method Validation: Provides a traceable standard for ensuring the precision, accuracy, and robustness of analytical methods in GLP/GMP environments.

Basic Information

Item	Detail
Product Name	Rac Pholedrine-D3
CAS No.	1286498-19-8
Molecular Formula	C11H14D3NO
Molecular Weight	181.27 g/mol
Synonyms	Pholedrine-d3; (±)-Pholedrine-d3; 4-[2-(Methylamino)propyl]phenol-d3; 4-Hydroxy-N-methylamphetamine-d3; para-Hydroxy-N-methylamphetamine-d3; para-Octopamine methyl ether-d3; Paredrinol-d3; Veritol-d3
EINECS	Contact for details

Quality Control

Every batch of Rac Pholedrine-D3 is manufactured and tested under strict quality management systems. We provide comprehensive analytical data to support your regulatory submissions, including detailed Certificates of Analysis (COA) with results for identity, purity (by HPLC), isotopic enrichment, and residual solvents. Our quality commitment ensures the material meets the stringent requirements for use as a certified reference standard in regulated laboratories.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term storage, consider storing at 2-8°C.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D3)	≥ 98.0 atom % D
Chemical Purity (NMR)	Conforms
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.