Description

4-[6-(4-Carbamimidoylphenoxy)-1,1,2,2,3,3,4,4,5,5,6,6-Dodecadeuteriohexoxy]Benzenecarboximidamide is a deuterated analog of a bis-benzamidine compound, offering enhanced metabolic stability and traceability for advanced research applications. This high-purity, isotopically labeled compound is critical for pharmacokinetic and metabolic studies, providing superior analytical precision. It is primarily utilized by pharmaceutical R&D teams, contract research organizations (CROs), and academic institutions engaged in drug discovery and development.

Application

• Internal Standard for LC-MS/MS: Serves as a stable, non-interfering internal standard for the precise quantification of its non-deuterated counterpart in bioanalytical assays.
• Drug Metabolism and Pharmacokinetics (DMPK) Studies: Used in absorption, distribution, metabolism, and excretion (ADME) studies to track drug pathways and metabolite formation.
• Protease Inhibitor Research: Acts as a deuterated reference compound in the development and screening of serine protease inhibitors.
• Biomedical Research: Employed in mechanistic studies to understand the role of amidine-based compounds in biological systems.
• Pharmaceutical Development: Supports the development of improved drug candidates with optimized stability profiles.

Basic Information

Product Name	4-[6-(4-Carbamimidoylphenoxy)-1,1,2,2,3,3,4,4,5,5,6,6-Dodecadeuteriohexoxy]Benzenecarboximidamide
CAS No.	1286461-12-8
Molecular Formula	C20H16D12N4O2
Molecular Weight	~376.56 g/mol
Synonyms	1,1'-[Oxybis(6,6,6,5,5,4,4,3,3,2,2,1-dodecadeuteriohexane-6,1-diyloxy-4,1-phenylene)]diguanidine; Deuterated Bisbenzamidine; D12-Bisbenzamidine; 4,4'-(Dodecadeuteriohexane-1,6-diylbis(oxy))dibenzamidine; 1,6-Bis(4-amidinophenoxy)hexane-d12; Contact for additional synonyms.
EINECS	Contact for details

Quality Control

Our deuterated compounds are manufactured under strict quality systems to ensure isotopic purity and chemical integrity. Each batch is characterized by advanced analytical techniques including NMR, HPLC, and mass spectrometry to confirm deuterium incorporation and chemical purity. A comprehensive Certificate of Analysis (COA) detailing isotopic purity, chemical purity, and analytical data is provided with every shipment to support your regulatory and research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term storage, consider storing desiccated at -20°C.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-content)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.