Description

Alclofenac-D5 is a deuterated analog of the non-steroidal anti-inflammatory drug (NSAID) Alclofenac, specifically designed for use as an internal standard in analytical chemistry. This high-purity, isotopically labeled compound is essential for ensuring the accuracy and reliability of quantitative mass spectrometry (MS) and liquid chromatography-mass spectrometry (LC-MS) analyses. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical testing facilities engaged in drug metabolism and pharmacokinetics (DMPK) studies, bioanalytical method development, and quality control of pharmaceutical products.

Application

• Internal Standard for Quantitative Bioanalysis: Serves as a critical reference compound in LC-MS/MS methods for the precise quantification of Alclofenac and its metabolites in biological matrices such as plasma, serum, and urine.
• Drug Metabolism and Pharmacokinetics (DMPK) Studies: Enables accurate tracking of the parent drug's absorption, distribution, metabolism, and excretion (ADME) profile in preclinical and clinical research.
• Pharmaceutical Impurity Profiling and Stability Testing: Used in method development to assess drug degradation pathways and ensure product stability and shelf-life.
• Forensic and Clinical Toxicology: Supports analytical methods for the detection and confirmation of Alclofenac in forensic or clinical casework.
• Isotope Dilution Mass Spectrometry (IDMS): Employed in high-accuracy measurement techniques to minimize matrix effects and improve analytical precision.

Basic Information

Product Name	Alclofenac-D5
CAS No.	1286448-70-1
Molecular Formula	C13H6D5Cl2NO3
Molecular Weight	292.15 g/mol (approx.)
Synonyms	2-[(2,6-Dichloro-3-methylphenyl)amino]benzeneacetic-3,4,5,6-d4-α-d1 Acid; 2-[(2,6-Dichloro-3-methylphenyl)amino]benzeneacetic-d5 Acid; Alclofenac-d5; [2,3,4,5,6-2H5]Alclofenac; Deuterated Alclofenac; Alclofenac (phenyl-d5); Alclofenac Internal Standard
EINECS	Contact for details

Quality Control

Every batch of Alclofenac-D5 is manufactured and analyzed under strict quality management protocols. We provide comprehensive analytical data to ensure the product meets the high-purity standards required for sensitive analytical applications. A detailed Certificate of Analysis (COA) is supplied with each shipment, reporting key parameters such as isotopic purity, chemical purity, and absence of unlabeled compound. Our quality systems are designed to support compliance with cGMP and ISO 9001 standards for research materials.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label or COA. The product is light-sensitive and should be stored away from direct light exposure. Keep the container in a dry, cool, and well-ventilated area.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥98.0%
Isotopic Purity (MS)	≥98.0 atom % D
Chemical Purity (NMR)	Conforms
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.