Description

Diflunisal-D3 is a deuterated internal standard specifically designed for analytical applications. This compound is essential for ensuring the accuracy and reliability of quantitative mass spectrometry (MS) and liquid chromatography-mass spectrometry (LC-MS) analyses. It is primarily used by pharmaceutical research and development laboratories, contract research organizations (CROs), and quality control facilities for precise pharmacokinetic studies, bioanalytical method development, and metabolite profiling.

Application

• Internal Standard for LC-MS/MS quantification of Diflunisal in biological matrices (plasma, serum, urine).
• Deuterated reference material for drug metabolism and pharmacokinetics (DMPK) studies.
• Critical component in bioanalytical method validation for regulatory submissions (FDA, EMA).
• Use in high-precision mass spectrometry to correct for analyte loss during sample preparation and instrument variability.
• Stable isotope-labeled standard for proteomics and metabolomics research applications.
• Quality control and assurance in pharmaceutical manufacturing for batch consistency testing.

Basic Information

Product Name	Diflunisal-D3
CAS No.	1286107-99-0
Molecular Formula	C13H5D3F2O3
Molecular Weight	254.21 g/mol
Synonyms	2',4'-Difluoro-4-hydroxy-3-(trideuteriomethyl)[1,1'-biphenyl]-3-carboxylic Acid; 5-(2,4-Difluorophenyl)-2-hydroxy-3-(trideuteriomethyl)benzoic Acid; [D3]-Diflunisal; Diflunisal (phenyl-D3); Diflunisal-d3; Deuterated Diflunisal; Diflunisal Internal Standard
EINECS	Contact for details

Quality Control

Our Diflunisal-D3 is manufactured under strict quality systems to ensure high chemical purity and isotopic enrichment suitable for sensitive analytical applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing results for identity, purity (HPLC), isotopic purity (D-content), and residual solvents. We support compliance with cGMP and ICH Q7 guidelines for active pharmaceutical ingredients (APIs) and reference standards.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature, 15-25°C (59-77°F). Keep the container in a dry, cool, and well-ventilated area.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-content)	≥ 99.0 atom % D
Chemical Purity (by HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH limits

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.