Description

3N-Benzyloxycarbonyl 3-Amino-2,2-Dimethylpropanamide-D6 is a high-purity, deuterium-labeled derivative of a key amino acid building block, designed for advanced research and development applications. Its core value lies in providing a stable, isotopically labeled standard essential for precise analytical quantification and metabolic pathway studies. This compound is particularly critical for pharmaceutical researchers, analytical chemists, and CROs engaged in drug discovery, pharmacokinetics, and proteomics, where accurate mass spectrometry and NMR analysis are paramount.

Application

• Internal Standard for LC-MS/MS: Serves as a critical quantitative reference standard in bioanalytical method development for drug and metabolite analysis.
• Metabolic Pathway Tracing: Used in deuterium labeling studies to investigate biochemical pathways and mechanisms of action in drug discovery.
• Proteomics Research: Employed in the synthesis of isotopically labeled peptides for mass spectrometry-based protein quantification (e.g., SILAC).
• Pharmaceutical Intermediate: Acts as a protected, labeled building block in the synthesis of novel active pharmaceutical ingredients (APIs) and candidates.
• NMR Spectroscopy: Provides a non-radioactive tracer for structural elucidation and dynamic studies in complex biological systems.
• Quality Control & Method Validation: Essential for validating analytical methods in GLP/GMP environments to ensure accuracy and reproducibility.

Basic Information

Product Name	3N-Benzyloxycarbonyl 3-Amino-2,2-Dimethylpropanamide-D6
CAS No.	1285902-39-7
Molecular Formula	C₁₄H₁₂D₆N₂O₃
Molecular Weight	268.34 g/mol
Synonyms	Z-3-Amino-2,2-dimethylpropionamide-D6; (3-(((Benzyloxy)carbonyl)amino)-2,2-dimethylpropanoyl)amide-D6; Cbz-3-Amino-2,2-dimethylpropanamide-D6; N-Carbobenzoxy-3-amino-2,2-dimethylpropionamide-D6; 3-[(Benzyloxycarbonyl)amino]-2,2-dimethylpropanamide-D6; Deuterated Cbz-Aib-NH2; Perdeuterated Z-Aib-NH2; 2,2-Dimethyl-3-[(phenylmethoxy)carbonylamino]propanamide-D6
EINECS	Contact for details

Quality Control

Every batch of 3N-Benzyloxycarbonyl 3-Amino-2,2-Dimethylpropanamide-D6 is manufactured under strict quality management systems and undergoes comprehensive analytical characterization. We guarantee high chemical and isotopic purity verified by NMR (¹H, ¹³C), Mass Spectrometry, and HPLC. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting purity, isotopic enrichment (D%), and confirming identity. Our quality protocols are designed to meet the stringent requirements of research and pre-clinical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under inert atmosphere (e.g., nitrogen or argon) after opening to maintain stability and prevent degradation. For long-term storage, consider storing at 2-8°C.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D%)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.