Description

1-Chloro-8-(Trifluoromethyl)Isoquinoline is a high-value, multi-functional heterocyclic building block characterized by its unique halogenated and fluorinated structure. This compound matters for its role as a critical intermediate in the synthesis of advanced materials and active pharmaceutical ingredients (APIs), where its specific substitution pattern enables precise molecular modifications. It is primarily needed by research chemists and process development teams in the pharmaceutical, agrochemical, and specialty chemical industries for creating novel compounds with targeted properties.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of potential drug candidates, particularly in kinase inhibitor research and other small-molecule therapeutics.
• Agrochemical Research: Used in the development of new pesticides and herbicides, where the trifluoromethyl group can enhance biological activity and metabolic stability.
• Material Science: Acts as a building block for creating organic electronic materials, such as ligands for OLEDs or charge-transport materials.
• Chemical Synthesis: Functions as a versatile scaffold for further functionalization via cross-coupling reactions, nucleophilic substitutions, or metal-catalyzed transformations.
• Ligand & Catalyst Development: Utilized in the design of novel ligands for transition metal catalysis due to the isoquinoline nitrogen's coordinating ability.
• Fluorine Chemistry Studies: Employed as a model compound in research exploring the effects of the trifluoromethyl group on reactivity and physicochemical properties.

Basic Information

Product Name	1-Chloro-8-(Trifluoromethyl)Isoquinoline
CAS No.	1283719-92-5
Molecular Formula	C10H5ClF3N
Molecular Weight	231.60 g/mol
Synonyms	8-(Trifluoromethyl)-1-chloroisoquinoline; 1-Chloro-8-trifluoromethylisoquinoline; Isoquinoline, 1-chloro-8-(trifluoromethyl)-; 1283719-92-5; 1-Chloro-8-(trifluoromethyl)isoquinoline
EINECS	Contact for details

Quality Control

Our 1-Chloro-8-(Trifluoromethyl)Isoquinoline is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high purity and consistent identity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results. Our commitment to quality ensures reliability for your most sensitive research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.