Description

(3Z)-6-Chloro-3-[(Dimethylamino)Methylene]-1,3-Dihydro-2H-Indol-2-One is a high-purity, synthetically valuable indole derivative. This compound serves as a critical advanced intermediate in the research and development of novel pharmaceutical agents, particularly in the areas of kinase inhibitors and other targeted therapies. It is essential for medicinal chemists and process development scientists in the pharmaceutical and biotechnology industries seeking to build complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of potential drug candidates, especially for oncology and CNS disorders.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization programs.
• Process Chemistry Development: Serves as a starting material or intermediate for scaling up synthetic routes under GMP conditions.
• Chemical Reference Standard: Utilized as a high-purity standard for analytical method development and validation in QC laboratories.
• Academic Research: Employed in university and institutional labs for exploring new organic reactions and heterocyclic chemistry.
• Bioconjugation & Probe Synthesis: Potential use in creating chemical probes for biochemical and biological assays.

Basic Information

Product Name	(3Z)-6-Chloro-3-[(Dimethylamino)Methylene]-1,3-Dihydro-2H-Indol-2-One
CAS No.	1283077-06-4
Molecular Formula	C12H11ClN2O
Molecular Weight	234.68 g/mol
Synonyms	6-Chloro-3-[(dimethylamino)methylene]-1,3-dihydro-2H-indol-2-one; (Z)-6-Chloro-3-[(dimethylamino)methylene]indolin-2-one; 6-Chloro-3-(dimethylaminomethylene)oxindole; 2H-Indol-2-one, 6-chloro-3-[(dimethylamino)methylene]-1,3-dihydro-, (3Z)-; 6-Chloro-3-(dimethylaminomethylene)-2-indolinone; CAS 1283077-06-4
EINECS	Contact for details

Quality Control

Our (3Z)-6-Chloro-3-[(Dimethylamino)Methylene]-1,3-Dihydro-2H-Indol-2-One is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for research and development. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing purity, identity, and impurity profiles. Our quality system is designed to meet the stringent requirements of pharmaceutical development partners.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from incompatible materials. For long-term storage, consider storage under an inert atmosphere.

Specification

Item	Specification
Appearance	Yellow to orange crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.