Description

5-Methyl-7-(Trifluoromethyl)-1,2,3,4-Tetrahydroisoquinoline is a high-value, fluorinated heterocyclic building block of significant interest in advanced organic synthesis. This compound matters for its unique structural motif, combining a tetrahydroisoquinoline scaffold with a strategically positioned trifluoromethyl group, which is crucial for modulating the physicochemical and biological properties of target molecules. It is primarily needed by pharmaceutical and agrochemical R&D organizations for the development of novel active ingredients, where its incorporation can enhance metabolic stability, lipophilicity, and binding affinity.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new drug candidates, particularly in central nervous system (CNS) and oncology therapeutic areas.
• Agrochemical Synthesis: Used as a building block for creating novel pesticides and herbicides, leveraging the bioactivity of the tetrahydroisoquinoline core.
• Material Science Research: Serves as a precursor for specialty chemicals and advanced materials, including liquid crystals and organic semiconductors.
• Fluorine Chemistry Studies: An important compound for academic and industrial research focused on introducing fluorine atoms into complex molecular architectures.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying enzyme function and biological pathways.

Basic Information

Product Name	5-Methyl-7-(Trifluoromethyl)-1,2,3,4-Tetrahydroisoquinoline
CAS No.	1280291-64-6
Molecular Formula	C11H12F3N
Molecular Weight	215.22 g/mol
Synonyms	7-(Trifluoromethyl)-5-methyl-1,2,3,4-tetrahydroisoquinoline; 5-Methyl-7-trifluoromethyl-1,2,3,4-tetrahydroisoquinoline; 1,2,3,4-Tetrahydro-5-methyl-7-(trifluoromethyl)isoquinoline; 1280291-64-6; 5-Methyl-7-(trifluoromethyl)-3,4-dihydro-1H-isoquinoline
EINECS	Contact for details

Quality Control

Our 5-Methyl-7-(Trifluoromethyl)-1,2,3,4-Tetrahydroisoquinoline is manufactured under a strict quality management system. Every batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistent composition. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.