Description

tert-Butyl (3-(4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl)Oxetan-3-Yl)Carbamate is a high-value, protected amine-containing boronic ester derivative that serves as a critical building block in modern synthetic chemistry. Its core value lies in enabling the precise construction of complex molecular architectures, particularly in pharmaceutical research and development. This compound is essential for medicinal chemists and process development scientists working on targeted therapies, including kinase inhibitors and other small molecule drugs.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially for targeted cancer therapies and kinase inhibitors.
• Suzuki-Miyaura Cross-Coupling Reactions: The pinacol boronate ester group enables efficient carbon-carbon bond formation with aryl/heteroaryl halides, a cornerstone reaction in drug discovery.
• Protected Amine Synthon: The tert-butyloxycarbonyl (Boc) protecting group allows for selective deprotection and further functionalization of the amine moiety under mild conditions.
• Ligand and Catalyst Development: Used in the research and synthesis of novel ligands and organocatalysts for asymmetric synthesis.
• Material Science Research: Employed as a monomer or functionalizing agent in the development of advanced polymers and organic electronic materials.
• Agrochemical Synthesis: Serves as an intermediate in the development of new, more effective crop protection agents.

Basic Information

Product Name	tert-Butyl (3-(4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl)Oxetan-3-Yl)Carbamate
CAS No.	1279090-25-3
Molecular Formula	C20H30BNO5
Molecular Weight	375.27 g/mol
Synonyms	3-[4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]-3-oxetanyl tert-butyl carbamate; tert-Butyl N-[3-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]oxetan-3-yl]carbamate; 3-Oxetanamine, 3-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]-, 1,1-dimethylethyl ester; Boc-protected 3-(4-Bpin-phenyl)oxetan-3-amine; (3-(4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)oxetan-3-yl)carbamic acid tert-butyl ester
EINECS	Contact for details

Quality Control

Our tert-Butyl (3-(4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl)Oxetan-3-Yl)Carbamate is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for research and development applications. All products undergo rigorous analytical testing, including HPLC, NMR, and MS, to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label or COA. This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when possible to maintain stability. Keep away from heat and open flame.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥97.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.