Description

Topiramate-D12 is a deuterium-labeled analog of the anticonvulsant drug Topiramate, specifically designed for use as an internal standard in quantitative analytical methods. This high-purity stable isotope-labeled compound is essential for ensuring accuracy and reliability in pharmacokinetic and metabolic studies, where precise measurement is critical. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical testing facilities specializing in bioanalytical method development and drug metabolism research.

Application

• Internal Standard for LC-MS/MS Analysis: Critical for the accurate quantification of Topiramate in biological matrices such as plasma, serum, and urine.
• Drug Metabolism and Pharmacokinetics (DMPK) Studies: Used to trace and measure the absorption, distribution, metabolism, and excretion (ADME) of the parent drug.
• Bioanalytical Method Development and Validation: Serves as a reference compound to establish robust, sensitive, and specific analytical assays.
• Clinical Research and Therapeutic Drug Monitoring (TDM): Enables precise measurement of drug concentrations in patient samples to optimize dosing regimens.
• Pharmaceutical Quality Control: Can be employed in impurity profiling and stability-indicating methods for drug substance and product analysis.

Basic Information

Product Name	Topiramate-D12
CAS No.	1279037-95-4
Molecular Formula	C12H9D12NO8S
Molecular Weight	351.40 g/mol
Synonyms	2,3:4,5-Bis-O-(1-methylethylidene)-β-D-fructopyranose sulfamate-d12; Topiramate (phenyl-d5, methyl-d7); Deuterated Topiramate; Topiramate-d12 Internal Standard; [D12]-Topiramate; 1H-Isoindole-1,3(2H)-dione, 2-(2,5-dioxo-1-pyrrolidinyl)- (9CI); Isotopically Labeled Topiramate
EINECS	Contact for details

Quality Control

Our Topiramate-D12 is manufactured under strict quality control protocols to ensure the highest isotopic and chemical purity required for sensitive analytical applications. Each batch is supported by comprehensive analytical data, including HPLC, NMR, and MS analysis to confirm identity, chemical purity, and isotopic enrichment. Certificates of Analysis (COA) detailing all specifications are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This compound is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider desiccant use and inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Isotopic Enrichment	≥98 atom % D
Chemical Purity	≥95.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.