Description

6A-Naltrexol-D4 is a deuterium-labeled internal standard of the primary metabolite of naltrexone, a critical tool for ensuring analytical accuracy and precision in quantitative bioanalysis. This high-purity reference material is essential for pharmaceutical research and development, particularly in pharmacokinetic and metabolic studies where precise quantification is non-negotiable. It is primarily used by analytical laboratories, CROs, and pharmaceutical companies engaged in method development and validation for clinical and forensic toxicology.

Application

• Internal Standard for LC-MS/MS quantification of 6β-naltrexol in biological matrices (plasma, serum, urine).
• Method Development and Validation in clinical pharmacology and forensic toxicology studies.
• Pharmacokinetic and Metabolism Research for naltrexone and related opioid antagonists.
• Quality Control and Assurance in the production of deuterated pharmaceutical reference standards.
• Doping Control Analysis for the detection of prohibited opioid antagonists in sports.
• Stability-Indicating Assay development for naltrexone-based pharmaceutical formulations.

Basic Information

Product Name	6A-Naltrexol-D4
CAS No.	1279034-32-0
Molecular Formula	C20H19D4NO4
Molecular Weight	345.44 g/mol
Synonyms	6β-Naltrexol-d4; 17-(Cyclopropylmethyl)-4,5α-epoxy-3,14-dihydroxymorphinan-6β-ol-d4; 6β-Naltrexol Tetradeuterated; Naltrexol Metabolite-d4; 6β-Hydroxynaltrexone-d4; 6β-Naltrexol Internal Standard; Deuterated 6β-Naltrexol; 6β-Naltrexol-6,7,8,14-d4
EINECS	Contact for details

Quality Control

Our 6A-Naltrexol-D4 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure high chemical and isotopic purity suitable for sensitive analytical applications. Certificates of Analysis (COA) detailing batch-specific results for identity, purity, and isotopic enrichment are provided and traceable to certified reference materials where applicable.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. This compound is hygroscopic (moisture-sensitive); ensure containers are sealed tightly after each use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (MS)	≥ 98.0 atom % D
Chemical Purity (NMR)	Conforms
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.